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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue

Figure 3

Effects of methotrexate on the expression of prostaglandin E 2 biosynthetic enzymes in rheumatoid synovium. Immunohistochemical evaluation of positive staining for microsomal prostaglandin E2 synthase 1 (mPGES-1), cyclooxygenase 1 (COX-1), and COX-2 in synovial tissue biopsies before and 8 weeks after initiation of methotrexate treatment. Results are expressed as a percentage of the positive stained area versus the total tissue area.

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