mRNA of selected molecular clocks over time in synovial fibroblasts. Results of patients with osteoarthritis (n = 6) and rheumatoid arthritis (n = 7) are demonstrated. One symbol represents the median value of mRNA of synovial fibroblast cultures of all included patients. The yellow area depicts the increase of the curve at different time points during an observation time of 72 hours. Typically mRNA starts with a huge peak after serum shock synchronization, which soon dies down. Abbreviations see legend to Figure 1.