Modulation by IL-1β and TNF of mRNA of clock proteins over time. Results of experiments with synovial fibroblasts of patients with rheumatoid arthritis are shown (n = 7). A) Mean of mRNA of molecular clock and influence of IL-1β (1 ng/ml) and TNF (1 ng/ml). Of every patient, the average value of mRNA was calculated from 36 time points during an observation period of 72 hours. The Box plot is generated from n = 7 median values of rheumatoid arthritis patients. Box plots give the 10th, 25th, 50th (median), 75th and 90th percentiles. *P < 0.05, **P < 0.01, #P < 0.005, ##P < 0.001 vs. respective control (Co). B) mRNA of selected molecular clocks over time in synovial fibroblasts of patients with rheumatoid arthritis (n = 7). One symbol represents the median value of mRNA of synovial fibroblast cultures of the seven patients at a given time point. The green control line is given for comparison (see Figure 3). Abbreviations see legend to Figure 1.