ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

Table 2 ERAP1 SNP analyses in Taiwanese AS patients and normal controls

SNP /Group	RA /RAF	Genotype /Frequency			Trend test P*	Genotype analysis		Allelic analysis
						P	OR (95% CI)	P	OR (95% CI)
rs27037	T	GG	GT	TT			GT + TT vs. GG		T vs. G
Normal (N = 1150)	0.415	0.341	0.488	0.171	4 × 10^-5	9.3 × 10^-5	1.49 (1.22-1.82)	5.5 × 10^-5	1.30 (1.15-1.48)
AS (N = 796)	0.481	0.258	0.524	0.219
rs27980	C	AA	AC	CC			AC + CC vs. AA		C vs. A
Normal (N = 1150)	0.538	0.215	0.494	0.291	0.035	0.024	1.31 (1.04-1.65)	0.033	1.15 (1.01-1.31)
AS (N = 797)	0.573	0.173	0.508	0.319
rs27044	G	CC	CG	GG			CG + GG vs. CC		G vs. C
Normal (N = 1149)	0.509	0.235	0.513	0.252	1.7 × 10^-4	1.7 × 10^-3	1.44 (1.15-1.81)	1.5 × 10^-4	1.28 (1.13-1.46)
AS (N = 796)	0.570	0.176	0.508	0.317
rs30187	T	CC	CT	TT			CT + TT vs. CC		T vs. C
Normal (N = 1150)	0.529	0.220	0.503 0.277		1.6 × 10^-3	6.1 × 10^-3	1.38 (1.10-1.74)	1.7 × 10^-3	1.23 (1.08-1.40)
AS (N = 797)	0.580	0.169	0.502	0.329

RA: Risk allele. RAF: Risk allele frequency. * The Trend test p-values were generated from 100,000 permutations.

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