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Table 2 ERAP1 SNP analyses in Taiwanese AS patients and normal controls

From: ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

SNP
/Group 		RA
/RAF 		Genotype
/Frequency 		Trend test
P* 		Genotype analysis Allelic analysis
       P OR (95% CI) P OR (95% CI)
rs27037 T GG GT TT    GT + TT vs. GG   T vs. G
Normal (N = 1150) 0.415 0.341 0.488 0.171 4 × 10-5 9.3 × 10-5 1.49 (1.22-1.82) 5.5 × 10-5 1.30 (1.15-1.48)
AS (N = 796) 0.481 0.258 0.524 0.219      
rs27980 C AA AC CC    AC + CC vs. AA   C vs. A
Normal (N = 1150) 0.538 0.215 0.494 0.291 0.035 0.024 1.31 (1.04-1.65) 0.033 1.15 (1.01-1.31)
AS (N = 797) 0.573 0.173 0.508 0.319      
rs27044 G CC CG GG    CG + GG vs. CC   G vs. C
Normal (N = 1149) 0.509 0.235 0.513 0.252 1.7 × 10-4 1.7 × 10-3 1.44 (1.15-1.81) 1.5 × 10-4 1.28 (1.13-1.46)
AS (N = 796) 0.570 0.176 0.508 0.317      
rs30187 T CC CT TT    CT + TT vs. CC   T vs. C
Normal (N = 1150) 0.529 0.220 0.503 0.277   1.6 × 10-3 6.1 × 10-3 1.38 (1.10-1.74) 1.7 × 10-3 1.23 (1.08-1.40)
AS (N = 797) 0.580 0.169 0.502 0.329      
  1. RA: Risk allele. RAF: Risk allele frequency. * The Trend test p-values were generated from 100,000 permutations.
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Arthritis Research & Therapy

ISSN: 1478-6362

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