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Table 3 ERAP1 SNP analyses in normal controls and AS patients positive and negative for syndesmophyte

From: ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

SNP
/Group 		RA
/RAF 		Genotype
/Frequency 		Trend test
P** 		Genotype analysis Allelic analysis
       P OR (95% CI) P OR (95% CI)
rs27037 T GG GT TT    GT + TT vs. GG   T vs. G
Normal (N = 1150) 0.415 0.341 0.488 0.171 7 × 10-5 2 × 10-4 1.64 (1.27-2.14) 7.8 × 10-5 1.39 (1.18-1.63)
AS Syn+ (N = 393) 0.496 0.239 0.529 0.232      
AS Syn- (N = 403) 0.465 0.275 0.519 0.206 0.215 0.243 1.21 (0.88-1.66) 0.217 1.13 (0.93-1.38)
Adjusted for HLA-B27+*      0.338 0.449 1.13 (0.82-1.57) 0.351 1.10 (0.90-1.34)
rs27980 C AA AC CC     AC + CC vs. AA   C vs. A
Normal (N = 1150) 0.538 0.215 0.493 0.291 9.9 × 10-3 0.011 1.49 (1.10-2.02) 9.4 × 10-3 1.24 (1.05-1.46)
AS Syn+ (N = 393) 0.592 0.155 0.506 0.338      
AS Syn- (N = 404) 0.555 0.191 0.510 0.300 0.134 0.188 1.28 (0.89-1.85) 0.134 1.16 (0.95-1.42)
Adjusted for HLA-B27+      0191 0.311 1.21 (0.83-1.77) 0.195 1.14 (0.93-1.40)
rs27044 G CC CG GG    CG + GG vs. CC   G vs. C
Normal (N = 1149) 0.509 0.235 0.513 0.252 7 × 10-5 10-4 1.85 (1.35-2.53) 9.8 × 10-5 1.38 (1.18-1.63)
AS Syn+ (N = 393) 0.589 0.143 0.537 0.321      
AS Syn-(N = 403) 0.552 0.208 0.479 0.313 0.136 0.015 1.59 (1.33-2.30) 0.136 1.16 (0.95-1.42)
Adjusted for HLA-B27+      0.271 0.050 1.46 (1.00-2.13) 0.277 1.12 (0.91-1.37)
rs30187 T CC CT TT    CT + TT vs. CC   T vs. C
Normal (N = 1150) 0.529 0.220 0.503 0.277 1.3 × 10-3 3 × 10-4 1.81 (1.31-2.50) 1.5 × 10-3 1.31 (1.11-1.54)
AS Syn+ (N = 393) 0.594 0.135 0.542 0.323      
AS Syn-(N = 404) 0.566 0.203 0.463 0.334 0.258 0.011 1.63 (1.12-2.38) 0.248 1.12 (0.92-1.37)
Adjusted for HLA-B27+      0.463 0.040 1.50 (1.02-2.20) 0.456 1.08 (0.88-1.32)
  1. RA: Risk allele. RAF: Risk allele frequency. The case-control association tests were performed in two subsets of the samples: (1) AS patients with syndesmophyte (AS Syn+) vs. normal controls; (2) AS patients with syndesmophyte (AS Syn+) vs. AS patients without syndesmophyte (AS Syn-). *Cochran -Mantel -Haenszel (CMH) tests for ERAP1 SNP and syndesmophyte associations, controlling for HLA-B27 positivity. ** The Trend test p-values were generated from 100,000 permutations.
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Arthritis Research & Therapy

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