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Table 4 ERAP1 SNP analyses in normal controls and AS patients positive and negative for HLA-B27

From: ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

SNP
/Group
RA
/RAF
Genotype
/Frequency
Trend test P** P Genotype analysis
OR (95% CI)
P Allelic analysis
OR (95% CI)
rs27037 T GG GT TT    GT + TT vs. GG   T vs. G
HLA-B27 + (N = 738) 0.488 0.245 0.534 0.221 0.042 5.6 × 10-3 2.17 (1.26-3.76) 0.038 1.50 (1.02-2.21)
HLA-B27 - (N = 58) 0.388 0.414 0.397 0.190      
Adjusted for syndesmophyte+*      0.057 9.1 × 10-3 2.10 (1.20-3.66) 0.056 1.46(0.99-2.16)
rs27980 C AA AC CC    AC + CC vs. AA   C vs. A
HLA-B27 + (N = 739) 0.578 0.165 0.514 0.321 0.172 0.034 1.93 (1.05-3.54) 0.147 1.32 (0.91-1.93)
HLA-B27 - (N = 58) 0.509 0.276 0.431 0.293      
Adjusted for syndesmophyte+      0.229 0.056 1.61 (0.99-3.38) 0.217 1.27 (0.87-1.86)
rs27044 G CC CG GG    CG + GG vs. CC   G vs. C
HLA-B27 + (N = 738) 0.580 0.163 0.515 0.323 6.3 × 10-3 7 × 10-4 2.71 (1.53-4.82) 5.8 × 10-3 1.70 (1.16-2.49)
HLA-B27 - (N = 58) 0.448 0.345 0.414 0.241      
Adjusted for syndesmophyte+      0.010 2.7 × 10-3 2.45 (1.36-4.39) 0.011 1.64 (1.12-2.42)
rs30187 T CC CT TT    CT + TT vs. CC   T vs. C
HLA-B27 + (N = 739) 0.589 0.156 0.510 0.334 6.1 × 10-3 4 × 10-4 2.86 (1.61-5.09) 5.4 × 10-3 1.71 (1.17-2.49)
HLA-B27 - (N = 58) 0.457 0.345 0.397 0.259      
Adjusted for syndesmophyte+      0.011 1.6 × 10-3 2.56 (1.43-4.61) 8.5 × 10-3 1.67 (1.14-2.45)
  1. RA: Risk allele. RAF: Risk allele frequency. * Cochran -Mantel -Haenszel tests for ERAP1 SNP and HLA-B27 associations, adjusted by syndesmophyte formation. ** The Trend test p-values were generated from 100,000 permutations. Sydesmophyte +: syndesmophyte formation positive