ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis

Table 4 ERAP1 SNP analyses in normal controls and AS patients positive and negative for HLA-B27

SNP /Group	RA /RAF	Genotype /Frequency			Trend test P**	P	Genotype analysis OR (95% CI)	P	Allelic analysis OR (95% CI)
rs27037	T	GG	GT	TT			GT + TT vs. GG		T vs. G
HLA-B27 + (N = 738)	0.488	0.245	0.534	0.221	0.042	5.6 × 10^-3	2.17 (1.26-3.76)	0.038	1.50 (1.02-2.21)
HLA-B27 - (N = 58)	0.388	0.414	0.397	0.190
Adjusted for syndesmophyte+*					0.057	9.1 × 10^-3	2.10 (1.20-3.66)	0.056	1.46(0.99-2.16)
rs27980	C	AA	AC	CC			AC + CC vs. AA		C vs. A
HLA-B27 + (N = 739)	0.578	0.165	0.514	0.321	0.172	0.034	1.93 (1.05-3.54)	0.147	1.32 (0.91-1.93)
HLA-B27 - (N = 58)	0.509	0.276	0.431	0.293
Adjusted for syndesmophyte+					0.229	0.056	1.61 (0.99-3.38)	0.217	1.27 (0.87-1.86)
rs27044	G	CC	CG	GG			CG + GG vs. CC		G vs. C
HLA-B27 + (N = 738)	0.580	0.163	0.515	0.323	6.3 × 10^-3	7 × 10^-4	2.71 (1.53-4.82)	5.8 × 10^-3	1.70 (1.16-2.49)
HLA-B27 - (N = 58)	0.448	0.345	0.414	0.241
Adjusted for syndesmophyte+					0.010	2.7 × 10^-3	2.45 (1.36-4.39)	0.011	1.64 (1.12-2.42)
rs30187	T	CC	CT	TT			CT + TT vs. CC		T vs. C
HLA-B27 + (N = 739)	0.589	0.156	0.510	0.334	6.1 × 10^-3	4 × 10^-4	2.86 (1.61-5.09)	5.4 × 10^-3	1.71 (1.17-2.49)
HLA-B27 - (N = 58)	0.457	0.345	0.397	0.259
Adjusted for syndesmophyte+					0.011	1.6 × 10^-3	2.56 (1.43-4.61)	8.5 × 10^-3	1.67 (1.14-2.45)

RA: Risk allele. RAF: Risk allele frequency. * Cochran -Mantel -Haenszel tests for ERAP1 SNP and HLA-B27 associations, adjusted by syndesmophyte formation. ** The Trend test p-values were generated from 100,000 permutations. Sydesmophyte +: syndesmophyte formation positive

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