ELABORATION | Time of evaluation during the studyc | EVALUATION | ||||||
---|---|---|---|---|---|---|---|---|
Proposed thresholda | Methodological techniqueb | Patient's perspectived | Physician's perspectivee | |||||
Se | Spe | LR+ (95% CI) | Se | Spe | LR+ (95% CI) | |||
ABSOLUTE CHANGE | ||||||||
a. ≥ 0.2 | 75th percentile at week 4 | Week 4 | 89.6 | 54.2 | 2.0 (1.3; 3.0) | 100.0 | 29.6 | 1.4 (1.2; 1.7) |
a. ≥ 0.2 | 75th percentile at week 4 | Week 12 | 96.1 | 40.9 | 1.6 (1.1; 2.3) | 93.3 | 17.6 | 1.1 (1.0; 1.3) |
b. ≥ 1 | Empirical/Correct classification at week 4 | Week 4 | 75.3 | 75.0 | 3.0 (1.5; 6.1) | 89.3 | 47.9 | 1.7 (1.3; 2.2) |
b. ≥ 1 | Empirical/Correct classification at week 4 | Week 12 | 90.8 | 54.5 | 2.0 (1.3; 3.2) | 88.9 | 27.5 | 1.2 (1.0; 1.5) |
c. ≥ 1.3 | SDC/75th percentile at week 12 | Week 4 | 75.3 | 79.3 | 3.6 (1.6; 8.0) | 85.7 | 47.9 | 1.6 (1.3; 2.2) |
c. ≥ 1.3 | SDC/75th percentile at week 12 | Week 12 | 88.2 | 59.1 | 2.2 (1.3; 3.6) | 84.4 | 29.4 | 1.2 (1.0; 1.5) |
d. ≥ 1.6 | ROC at week 4 | Week 4 | 72.7 | 87.5 | 5.8 (2.0; 16.9) | 85.7 | 53.5 | 1.8 (1;4; 2.5) |
d. ≥ 1.6 | ROC at week 4 | Week 12 | 84.2 | 63.6 | 2.3 (1.3; 4.1) | 82.2 | 33.3 | 1.2 (1.0; 1.6) |
e. ≥ 2 | Empirical/Correct classification at week 4 | Week 4 | 67.5 | 87.5 | 5.4 (1.9; 15.7) | 78.6 | 56.3 | 1.8 (1.3; 2.5) |
e. ≥ 2 | Empirical/Correct classification at week 4 | Week 12 | 78.9 | 63.6 | 2.2 (1.2; 3.8) | 77.8 | 37.3 | 1.2 (1.0; 1.6) |
f. ≥ 2.5 | Correct classification at week 12 | Week 4 | 59.7 | 95.8 | 14.3 (2.1; 98.5) | 71.4 | 64.8 | 2.0 (1.4; 3.0) |
f. ≥ 2.5 | Correct classification at week 12 | Week 12 | 69.7 | 68.2 | 2.2 (1.2; 4.1) | 77.8 | 52.9 | 1.7 (1.2; 2.3) |
g. ≥ 3 | ROC at week 12 | Week 4 | 41.6 | 95.8 | 10.0 (1.4; 69.2) | 57.1 | 77.5 | 2.5 (1.5; 4.3) |
g. ≥ 3 | ROC at week 12 | Week 12 | 63.2 | 90.9 | 6.9 (1.8; 26.3) | 71.1 | 64.7 | 2.0 (1.3; 3.1) |
RELATIVE CHANGE | ||||||||
a. ≥ 6% | 75th percentile at week 4 | Week 4 | 88.3 | 54.2 | 1.9 (1.2; 3.0) | 100.0 | 31.0 | 1.4 (1.2; 1.7) |
a. ≥ 6% | 75th percentile at week 4 | Week 12 | 96.1 | 45.5 | 1.6 (1.2; 2.6) | 93.3 | 19.6 | 1.2 (1.0; 1.4) |
b. ≥ 17% | ROC at week 4 | Week 4 | 80.5 | 75.0 | 3.2 (1.6; 6.5) | 100.0 | 46.5 | 1.9 (1.5; 2.3) |
b. ≥ 17% | ROC at week 4 | Week 12 | 94.7 | 59.1 | 2.3 (1.4; 3.8) | 91.1 | 25.5 | 1.2 (1.0; 1.5) |
c. ≥ 20% | Empirical | Week 4 | 76.6 | 75.0 | 3.1 (1.5; 6.2) | 96.4 | 49.3 | 1.9 (1.5; 2.4) |
c. ≥ 20% | Empirical | Week 12 | 90.8 | 59.1 | 2.2 (1.3; 3.7) | 88.9 | 27.5 | 1.2 (1.0; 1.5) |
d. ≥ 25% | Correct classification at week 4/75th percentile at week 12 | Week 4 | 76.6 | 75.0 | 3.1 (1.5; 6.2) | 96.4 | 49.3 | 1.9 (1.5; 2.4) |
d. ≥ 25% | Correct classification at week 4/75th percentile at with 12 | Week 12 | 88.2 | 63.6 | 2.4 (1.4; 4.2) | 88.9 | 33.3 | 1.3 (1.1; 1.7) |
e. ≥ 30% | 75th percentile at week 12 | Week 4 | 67.5 | 87.5 | 5.4 (1.9; 15.7) | 92.9 | 62.0 | 2.4 (1.8; 3.3) |
e. ≥ 30% | 75th percentile at week 12 | Week 12 | 84.2 | 63.6 | 2.3 (1.3; 4.1) | 86.7 | 37.3 | 1.4 (1.1; 1.8) |
f. ≥ 35% | ROC at week 12 | Week 4 | 63.6 | 91.7 | 7.6 (2.0; 29.1) | 85.7 | 64.8 | 2.4 (1.7; 3..5) |
f. ≥ 35% | ROC at week 12 | Week 12 | 81.6 | 72.7 | 3.0 (1.5; 6.0) | 86.7 | 43.1 | 1.5 (1.2; 2.0) |
g. ≥ 42% | Correct classification at week 12 | Week 4 | 59.7 | 95.8 | 14.3 (2.1; 98.5) | 82.1 | 69.0 | 2.7 (1.8; 3.9) |
g. ≥ 42% | Correct classification at week 12 | Week 12 | 72.4 | 72.7 | 2.7 (1.3; 5.3) | 82.2 | 52.9 | 1.7 (1.3; 2.4) |
h. ≥ 50% | Empirical | Week 4 | 53.2 | 100.0 | ND | 78.6 | 76.1 | 3.3 (2.1; 5.2) |
h. ≥ 50% | Empirical | Week 12 | 67.1 | 86.4 | 4.9 (1.7; 14.3) | 75.6 | 60.8 | 1.9 (1.3; 2.8) |