TY - JOUR AU - Schirmer, Michael AU - Goldberger, Christian AU - Würzner, Reinhard AU - Duftner, Christina AU - Pfeiffer, Karl-P AU - Clausen, Johannes AU - Neumayr, Günther AU - Falkenbach, Albrecht PY - 2001 DA - 2001/10/16 TI - Circulating cytotoxic CD8+ CD28- T cells in ankylosing spondylitis JO - Arthritis Research & Therapy SP - 71 VL - 4 IS - 1 AB - Circulating CD8+ CD28- T cells were found to be expanded more in patients with ankylosing spondylitis than in an age-matched healthy population (41.2 ± 17.7% versus 18.6 ± 7.6%). The level of CD8+CD28- T cells was dependent on the disease status, but was independent of age. Most of the CD8+ CD28- T cells produced perforin after stimulation in vitro, in contrast to their CD8+CD28+ counterparts. From the clinical perspective, the percentage of the cytotoxic CD8+ CD28- T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P = 0.032). SN - 1478-6362 UR - https://doi.org/10.1186/ar386 DO - 10.1186/ar386 ID - Schirmer2001 ER -