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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis

Figure 2

Vascular reactivity to vasodilators and vasoconstrictive agents. Experiments were performed on thoracic aortic rings from control rats, AIA rats and nor-NOHA AIA rats 21 days after the onset of arthritis. A, Concentration - response curve for Ach in endothelium-intact rings preconstricted with NE 3 × 10-7 moles/liter. B, Concentration - response curve for SNP in endothelium-denuded rings preconstricted with NE 3 × 10-7 moles/liter. C, Concentration - response curve for NE in endothelium-denuded rings, D, Concentration - response curve for ANG-II in endothelium-denuded rings, E, Concentration - response curve for ET-1 in endothelium-denuded rings. Values are the mean ± SEM from 8 to 12 rings. * = P < 0.05. KKCl = Krebs potassium chloride solution.

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Arthritis Research & Therapy

ISSN: 1478-6362

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