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Table 1 Clinical, histological and radiological scores and plasma levels of IL-6 and VEGF

From: Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis

  control rats
(n= 8)
AIA rats
(n= 20)
nor-NOHA treated rats
(n= 20)
Body weight (g) 310 ± 3 279 ± 10* 269 ± 5*
Arthritis score 0 1.3 ± 0.2* 1.1 ± 0.2*
Ankle diameter (mm) 7.6 ± 0.1 8.3 ± 0.2* 8.3 ± 0.1*
Histological score 0 4.1 ± 3.7 ± 1*
Radiological score 0 2.2 ± 2.1 ± 0.6*
IL-6 (pg/ml) 366 ± 22 419 ± 17* 378 ± 22
VEGF (pg/ml) 488 ± 36 642 ± 34* 500 ± 65
  1. Data were obtained 21 days after the onset of arthritis in control rats, AIA rats and nor-NOHA treated rats. Values are the mean ± SEM. * = P <0.05 vs control