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Table 1 Clinical, histological and radiological scores and plasma levels of IL-6 and VEGF

From: Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis

 

control rats

(n= 8)

AIA rats

(n= 20)

nor-NOHA treated rats

(n= 20)

Body weight (g)

310 ± 3

279 ± 10*

269 ± 5*

Arthritis score

0

1.3 ± 0.2*

1.1 ± 0.2*

Ankle diameter (mm)

7.6 ± 0.1

8.3 ± 0.2*

8.3 ± 0.1*

Histological score

0

4.1 ±

3.7 ± 1*

Radiological score

0

2.2 ±

2.1 ± 0.6*

IL-6 (pg/ml)

366 ± 22

419 ± 17*

378 ± 22

VEGF (pg/ml)

488 ± 36

642 ± 34*

500 ± 65

  1. Data were obtained 21 days after the onset of arthritis in control rats, AIA rats and nor-NOHA treated rats. Values are the mean ± SEM. * = P <0.05 vs control
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Arthritis Research & Therapy

ISSN: 1478-6362

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