Upregulation of tumor necrosis factor receptor-associated factor 6 correlated with synovitis severity in rheumatoid arthritis

Table 2 Correlation between synovial TRAF6 expression and parameters of inflammation or joint destruction in RA patients^▲

	Intimal TRAF6		Subintimal TRAF6		Total TRAF6
	R	P	r	P	r	P
*Synovial inflammation*
Synovitis score	0.239	0.119	0.465	0.001**	0.412	0.006**
hyperplasia of intima	0.232	0.130	0.277	0.068	0.269	0.077
Inflammatory cell infiltration	0.164	0.286	0.450	0.002**	0.367	0.014*
Cellular density of the synovial stroma	0.147	0.340	0.118	0.444	0.164	0.288
CD3+ T cells	0.367	0.033*	0.526	0.001**	0.478	0.004**
CD20+ B cell	0.165	0.343	0.359	0.034*	0.313	0.047*
CD38+ plasma cells	0.200	0.250	0.391	0.020*	0.390	0.020**
Subintimal CD68+ cells	0.356	0.074	0.562	0.003*	0.532	0.005**
Intimal CD68+ cells	0.631	0.000***	0.604	0.000***	0.636	0.000***
MCV	0.578	0.005**	0.522	0.013*	0.569	0.006**
CD79a+ B lineage cells	0.154	0.426	0.417	0.024*	0.398	0.032*
*Disease duration*	-0.161	0.298	-0.144	0.352	-0.145	0.347
*Disease activity*
DAS28CRP	-0.186	0.226	-0.179	0.245	-0.157	0.308
CRP	0.102	0.513	0.103	0.510	0.128	0.413
ESR	-0.133	0.394	-0.058	0.710	-0.057	0.719
RF	-0.094	0.546	-0.003	0.986	0.005	0.975
ACPA	-0.067	0.692	0.110	0.517	0.058	0.733
*Joint destruction*
Joint space narrowing subscore	-0.182	0.238	-0.103	0.508	-0.106	0.493
Erosion subscore	-0.233	0.128	-0.125	0.419	-0.145	0.347
Total Sharp score	-0.182	0.238	-0.076	0.622	-0.085	0.583

^▲Spearman's rank order correlation test was used to assess the correlation between synovial TRAF6 expression and the histological, clinical or joint destruction parameters in 44 RA patients.
ACPA, anti-cyclic citrullinated peptide antibody; DAS28, Disease Activity Score 28-joint assessment; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; MCV, microvascular count;RA, rheumatoid arthritis; RF, rheumatoid factor; *P < 0.05, ** P < 0.01, *** P < 0.001.

ISSN: 1478-6362