Figure 5

Local profile of inflammatory mediators in the delayed-type hypersensitivity (DTH)-arthritis response. Levels were measured by multiplex bead-based luminex analysis on homogenate supernatants from whole paws taken at 12, 24, and 48 hours and 4, 9, and 14 days after induction of DTH arthritis (n = 5 per time point). The line represents the median. *P ≤ 0.05, **P ≤ 0.01, compared with control value. CXCL, chemokine (C-X-C motif) ligand; IFNγ, interferon-gamma; IL, interleukin; IP-10, interferon-gamma inducible protein 10; MCP-1, monocyte chemo attractant protein 1; RANKL, receptor activator of nuclear factor kappa-B ligand; TNFα, tumor necrosis factor-alpha.