Figure 4

Interleukin (IL)-7 promotes expansion of splenic T and B cells. Total number of thymocytes was not affected by IL-7. The absolute numbers of CD4CD8 double negative (DN), CD4CD8 double positive (DP), and single-positive CD4 and CD8 thymocytes were not changed by treatment with IL-7 (A). Peripheral cell numbers, measured by total numbers of splenocytes, CD4⁺ T cells, CD8⁺ T cells, CD19⁺ B cells, and germinal center (GL7⁺) B cells were all increased by IL-7 compared with PBS treatment (B). Values are expressed as mean ± SEM of 15 mice per group. Statistical differences with PBS group of *P < 0.05 or **P < 0.005.