Skip to main content

Table 3 Univariate associations between ADORA3 rs1544224 and disease activity.

From: Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action

Variable Genotypea Allelic Pvalue
  11 12 22  
SJC (28) 2.9 ± 3.4 2.7 ± 3.9 3.0 ± 3.0 0.89
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
TJC (28) 2.5 ± 3.5 2.4 ± 3.9 1.7 ± 2.3 0.65
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
DAS28 2.9 ± 1.2 2.9 ± 1.3 2.9 ± 1.1 0.99
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
CRP 1.2 ± 2.1 1.1 ± 1.4 1.1 ± 0.9 0.98
  105 (46.7%) 66 (29.3%) 16 (7.1%)  
Physicians global 23.5 ± 19.5 22.0 ± 19.8 15.5 ± 12.7 0.26
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
Physicians response to MTX 22.9 ± 18.9 22.2 ± 20.7 14.5 ± 13.6 0.23
  118 (52.4%) 71 (9.3%) 18 (8.2%)  
Pain VAS 23.6 ± 22.8 22.8 ± 23.9 20.1 ± 22.9 0.83
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
Patient global 26.4 ± 21.9 27.6 ± 24.6 23.7 ± 17.1 0.79
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
mHAQ 0.42 ± 0.49 0.42 ± 0.45 0.37 ± 0.47 0.89
  123 (54.7%) 84 (37.6%) 18 (8.2%)  
  1. a1 = major allele, 2 = minor allele of rs1544224. Top row mean ± SD, bottom row number of patients. CRP, C-reactive protein; DAS28, disease activity score in 28 joints; HAQ, Health Assessment Questionnaire; MTX, methotrexate; SD, standard deviation; SJC, swollen joint count; TJC, tender joint count; VAS, visual analog scale.