Variable | Comparison groups | Optimal cut point | Sensitivity (95% CI) | Specificity (95% CI) | +LR | -LR | AUC |
---|---|---|---|---|---|---|---|
NT-proBNP (ng/ml) | PAH versus control | ≥ 209.8 | 92.9% (64.1%-99.6%) | 100% (85.9%-99.7%) | - | 0.07 (0.01-0.47) | 0.93 (0.80-1.0) |
 | PAH versus ILD | ≥ 360.5 | 85.7% (56.2%-97.0%) | 100.0% (71.8%-99.5%) | - | 0.14 (0.04-0.52) | 0.92 (0.78-1.0) |
DLCOcorr% | PAH versus control | < 70.3 | 100% (73.2%-99.3%)a | 100% (85.7%-99.7%)a | - | - | 1.0 |
 | PAH versus ILD | Nil | - | - | - | - | 0.42 (0.22-0.63) |
FVC/DLCO | PAH versus control | ≥ 1.66 | 64.3% (35.6%-86.0%) | 96.7% (80.9%-99.8%) | 19.3 (2.7- .) | 0.37 (0.18-0.75) | 0.90 (0.78-1.0) |
 | PAH versus ILD | ≥ 1.82 | 50.0% (24.0%-76.0%) | 94.4% (70.6%-99.7%) | 9.0 (1.2-64.9) | 0.53 (0.31-0.90) | 0.71 (0.51-0.90) |
DLCO < 70.3% and FVC/DLCO ≥ 1.82 | PAH versus control | - | 50.0% (24.0%-76.0%) | 100% (85.9%-99.7%) | - | 0.63 (0.43-0.91) | - |
 | PAH versus ILD | - | 50.0% (24.0%-76.0%) | 94.4% (70.6%-99.7%) | 6.75 (0.9-50.2) | 0.66 (0.45-0.98) | - |
DLCO < 70.3% and FVC/DLCO ≥ 1.82 (A) and/or NT-proBNP ≥ 209.8 (B) | PAH versus control | - | 100% (73.2%-99.3%)a | 100% (85.9%-99.7%)a | - | - | - |
 | PAH versus ILD | - | 100% (73.2%-99.3%)a | 77.8% (51.9%-92.6%) | 4.50 (1.90-10.7) | - | - |