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Table 2 Efficacy parameters

From: Exercise training in pulmonary arterial hypertension associated with connective tissue diseases

Characteristic

Baseline (n= 21)

3 weeks (n= 21)

P-value

15 weeks (n= 14)

P-value

6-minute walking distance, m

Mean change

386

±

121

425

±

118

 

447

±

139

 
    

64

±

17

< 0.001a

71

±

35

0.003

95% CI for the difference to baseline

42

-

85

 

48

-

95

 

Quality of life questionnaire SF36, score

Physical functioning

33.5

±

20

   

0.025b

45.2

±

20

0.025b

Role-physical

60.4

±

36

   

0.317

65.6

±

23

0.317

Bodily pain

58.1

±

33

   

0.260

62.2

±

31

0.260

General health perception

31.6

±

15

   

0.049b

35.9

±

14

0.049b

Vitality

38.1

±

14

   

0.021b

48.1

±

18

0.021b

Social functioning

61.8

±

30

   

0.008a

71.4

±

23

0.008a

Role-emotional

77.6

±

22

   

0.115

91.6

±

14

0.115

Mental Health

56.8

±

21

   

0.033b

66.2

±

16

0.033b

Cardiopulmonary exercise testing

Peak VO2/kg, mL/min/kg

11.8

±

3.4

13.6

±

3.4

0.010b

14.1

±

3.5

0.008a

Peak VO2, ml/min

822

±

252

882

±

218

0.011b

887

±

139

0.007a

EqCO2 at AT, ml/min

41.3

±

8.9

41.3

±

9.5

0.529

42.8

±

7.1

0.138

VO2 at AT; ml/min

619

±

172

689

±

207

0.013b

681

±

207

0.012b

Oxygen pulse, (mL/min)/min-1

6.7

±

1.6

6.8

±

1.8

0.127

6.3

±

0.4

0.260

HR rest, min-1

85

±

14

77

±

12

0.0001a

78

±

16

0.045b

HR max, min-1

122

±

21

127

±

18

0.076

140

±

20

0.005a

RRsys rest, mmHg

117

±

17

114

±

15

0.092

111

±

15

0.653

RRdiast rest, mmHg

75

±

8

71

±

9

0.038b

72

±

8

0.464

RRsys max, mmHg

149

±

28

154

±

18

0.743

153

±

18

0.002a

RRdias max, mmHg

85

±

13

88

±

14

0.292

88

±

12

0.083

Oxygen saturation rest, %

94.7

±

3.0

96.7

±

3.2

0.266

96.4

±

2.8

0.421

Oxygen saturation max, %

89.8

±

5.6

90.8

±

5.8

0.052

91.7

±

6.3

0.018b

sPAP rest, mmHg

52

±

14

47

±

9

0.005a

50

±

10

0.210

sPAP max, mmHg

85

±

26

87

±

20

0.959

89

±

14

0.320

Workload max, W

55

±

19

67

±

23

0.007a

65

±

20

0.008a

Borg Scale, score

16

±

2

15

±

2

0.171

15

±

1

0.105

Laboratory parameters

C-reactive protein, mg/l

15.2

±

22.5

8.3

±

9.7

0.069

6.6

±

5.3

0.071

Leucocytes, 109/l

9.2

±

7.5

10.0

±

12.9

0.071

8.6

±

7.6

0.177

NT-proBNP, pg/ml

1928

±

4623

1101

±

1380

0.164

2321

±

2671

0.646

  1. Values are mean ± standard deviation. aP < 0.01, bP < 0.05 in comparison to baseline; P-values are the same for absolute values and differences. 6-minute walking distance data were analyzed by the two-sided Student t-test; cardiopulmonary exercise testing data were analyzed by the Wilcoxon test. CI: confidence interval; SF-36: short-form Health Survey Questionnaire; VO2/kg: maximum oxygen consumption/kg; EqCO2: ventilatory equivalent for carbon dioxide; HR: heart rate; RRsys: systolic blood pressure; RRdiast: diastolic blood pressure; sPAP: systolic pulmonary arterial pressure; NT-proBNP: N-terminal prohormone of brain natriuretic peptide.