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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Figure 4

Effect of injection of HA on synovial histology at Day 4 and Day 19 of model. (A) Typical images of proximal (Prox) and distal (Dist) regions of the perimeniscal synovium from Hematoxylin&Eosin stained sections are shown for five experimental groups (Naïve, Acute, Acute+ HA, TTR and TTR+HA). Histological changes were identified as: hyperplasia (H), fibrosis (F) and neovascularization (V). (B) Mean pathology scores for fibrosis (F) and vascularization (V) were obtained from 16 stained sections per mouse (n = 4 mice for each of the four experimental groups Naïve, TTR, TTR+HA, TTR+SA) and statistical analysis performed as described in the Methods section.

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