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Table 4 QPCR of Adamts5 expression in cartilage/subchondral bone and meniscus/synovium

From: Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

 

CARTILAGE/SC BON

MENISCUS/SYNOVIUM

 

Adamts5

P

Fold 5

Adamts5

Fold5

 

ΔCT1

  

ΔCT1

 

Naive

8.85 (0.55)

 

1.00

8.31

1.00

TTR

5.94 (0.44)

.00173

7.51

1.90

85.1

TTR+HA

7.56 (0.86)

.0414

2.44

5.35

7.84

TTR+SA

6.22 (1.24)

.0094

6.20

-0.17

357

  1. 1relative to GAPDH, mean (SD) ΔCT of 8 pools with 2 mice per pool for Naïve and 12 pools with 2 mice per pool for all 4 treatment groups.
  2. 2relative to GAPDH, mean (SD) ΔCT of 2 pools with 8 mice per pool for Naïve and 2 pools with 12 mice per pool for all 4 treatment groups. Values represent the average of the two pools, with the difference between duplicates being < 20% of average pool value. P-values: 3TTR vs Naive; 4TTR+HA or TTR+SA vs TTR;
  3. 5Fold Changes are relative to Naive
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Arthritis Research & Therapy

ISSN: 1478-6362

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