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Table 1 Reactivity of autoimmune patient sera with components of the human exosome

From: Autoantibodies directed to novel components of the PM/Scl complex, the human exosome

Exosome component IIM [no. (%)] Myositis/scleroderma overlap syndrome [no. (%)] Scleroderma [no. (%)]
Total number analyzed 48 10 11
PM/Scl-100a 45 (94) 10 (100) 11 (100)
PM/Scl-75a 26 (54) 9 (90) 7 (64)
hRrp4pb 25 (52) 6 (60) 7 (64)
hRrp40pb 3 (6) 1 (10) 0
hRrp41pb 5 (10) 0 0
hRrp42pb 11 (23) 2 (20) 4 (36)
hRrp46pb 6 (13) 0 0
hCsl4pb 7 (15) 0 0
Total reactivity with novel components 30 (63) 6 (60) 8 (73)
  1. aAnti-PM/Scl-100 and anti-PM/Scl-75 reactivity of IIM sera was previously analyzed [28]. bNovel human exosome components analyzed in this study. IIM = idiopathic inflammatory myopathies; PM/Scl = polymyositis/scleroderma.