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Table 1 Pooled analysis of CD40 polymorphisms

From: Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis

SNP Change Samples set N Minor allele,
no. (frequency)
Pvalue OR [95% CI] P-BD
rs1883832 T/C Controls 3,138 1,427 (0.277)    
   SSc 2,605 1,424 (0.274) 0.610 1.02 [0.94-1.11] 0.904
   lcSSc 1,758 987 (0.276) 0.246 1.06 [0.96-1.16] 0.496
   dcSSc 860 451 (0.271) 0.683 0.97 [0.86-1.10] 0.446
   ACA + 1,077 592 (0.261) 0.879 1.01 [0.90-1.13] 0.355
   ATA + 716 416 (0.293) 0.108 1.11 [0.98-1.26] 0.946
   Pulmonary fibrosis 702 394 (0.278) 0.433 1.05 [0.92-1.20] 0.802
rs4810485 G/T Controls 3,122 1,652 (0.272)    
   SSc 2,560 1,388 (0.274) 0.420 1.04 [0.95-1.13] 0.935
   lcSSc 1,736 967 (0.277) 0.155 1.07 [0.97-1.18] 0.481
   dcSSc 839 436 (0.269) 0.817 0.99 [0.87-1.12] 0.600
   ACA + 1,071 580 (0.257) 0.844 1.01 [0.90-1.13] 0.399
   ATA + 699 402 (0.292) 0.080 1.12 [0.99-1.28] 0.890
   Pulmonary fibrosis 682 375 (0.272) 0.483 1.05 [0.92-1.20] 0.605
rs1535045 T/C Controls 3,147 1,595 (0.247)    
   SSc 2,585 1,272 (0.243) 0.275 0.95 [0.88-1.04] 0.560
   lcSSc 1,749 860 (0.251) 0.375 0.96 [0.87-1.05] 0.334
   dcSSc 850 411 (0.228) 0.275 0.93 [0.82-1.06] 0.746
   ACA + 1,075 525 (0.241) 0.348 0.95 [0.84-1.06] 0.844
   ATA + 707 369 (0.264) 0.669 1.03 [0.90-1.18] 0.640
   Pulmonary fibrosis 696 340 (0.250) 0.396 0.94 [0.82-1.08] 0.028
  1. Controls are used as reference for all comparisons. All P values have been calculated for the allelic model by using the Mantel-Haenszel test under fixed effect. P_BD, P value by the Breslow-Day method.