Table 1 Pooled analysis of CD40 polymorphisms
From: Analysis of the association between CD40 and CD40 ligand polymorphisms and systemic sclerosis
SNP | Change | Samples set | N | Minor allele, no. (frequency) | Pvalue | OR [95% CI] | P-BD |
|---|---|---|---|---|---|---|---|
rs1883832 | T/C | Controls | 3,138 | 1,427 (0.277) | |||
SSc | 2,605 | 1,424 (0.274) | 0.610 | 1.02 [0.94-1.11] | 0.904 | ||
lcSSc | 1,758 | 987 (0.276) | 0.246 | 1.06 [0.96-1.16] | 0.496 | ||
dcSSc | 860 | 451 (0.271) | 0.683 | 0.97 [0.86-1.10] | 0.446 | ||
ACA + | 1,077 | 592 (0.261) | 0.879 | 1.01 [0.90-1.13] | 0.355 | ||
ATA + | 716 | 416 (0.293) | 0.108 | 1.11 [0.98-1.26] | 0.946 | ||
Pulmonary fibrosis | 702 | 394 (0.278) | 0.433 | 1.05 [0.92-1.20] | 0.802 | ||
rs4810485 | G/T | Controls | 3,122 | 1,652 (0.272) | |||
SSc | 2,560 | 1,388 (0.274) | 0.420 | 1.04 [0.95-1.13] | 0.935 | ||
lcSSc | 1,736 | 967 (0.277) | 0.155 | 1.07 [0.97-1.18] | 0.481 | ||
dcSSc | 839 | 436 (0.269) | 0.817 | 0.99 [0.87-1.12] | 0.600 | ||
ACA + | 1,071 | 580 (0.257) | 0.844 | 1.01 [0.90-1.13] | 0.399 | ||
ATA + | 699 | 402 (0.292) | 0.080 | 1.12 [0.99-1.28] | 0.890 | ||
Pulmonary fibrosis | 682 | 375 (0.272) | 0.483 | 1.05 [0.92-1.20] | 0.605 | ||
rs1535045 | T/C | Controls | 3,147 | 1,595 (0.247) | |||
SSc | 2,585 | 1,272 (0.243) | 0.275 | 0.95 [0.88-1.04] | 0.560 | ||
lcSSc | 1,749 | 860 (0.251) | 0.375 | 0.96 [0.87-1.05] | 0.334 | ||
dcSSc | 850 | 411 (0.228) | 0.275 | 0.93 [0.82-1.06] | 0.746 | ||
ACA + | 1,075 | 525 (0.241) | 0.348 | 0.95 [0.84-1.06] | 0.844 | ||
ATA + | 707 | 369 (0.264) | 0.669 | 1.03 [0.90-1.18] | 0.640 | ||
Pulmonary fibrosis | 696 | 340 (0.250) | 0.396 | 0.94 [0.82-1.08] | 0.028 |