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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus

Figure 5

Monocytes and mDCs production of IFN-α/TNF-α upon TLR-4 stimulation in SLE subjects treated with HCQ. Flow cytometric analysis (left) of IFN-α and TNF-α production after TLR-4 (lipopolysaccharide, LPS) stimulation of monocytes (CD14+) (top, left) and mDCs, (CD11c+) (bottom) in a representative subject. Comparison of the frequency of monocytes (CD14+) (right top) and mDCs (CD11c+) (right bottom) cells producing TNF-α after TLR-4 stimulation between SLE subjects that were treated (white squares) or not (black triangles) with HCQ. In each case, lines represented the mean value and error bars the standard deviation.

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Arthritis Research & Therapy

ISSN: 1478-6362

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