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Table 2 Comparison of the ACR/EULAR RA remission definition candidate for patients meeting ACR/EULAR classification criteria for rheumatoid arthritis (ESPOIR STUDY).

From: Validation of ACR/EULAR definition of remission in rheumatoid arthritis from RA practice: the ESPOIR cohort

  Prevalence of good outcome in patients**:   
Candidate remission definition (* definitions are those recommended by ACR/EULAR) In remission Not in remission * Positive likelihood ratio
*(95% CI)
P-value
Boolean-based definition
TJC28, SJC28, CRP ≤ 1 25% (29/118) 12% 1.4 (1.1, 1.7) 0.0526
TJC28, SJC28, CRP, PhGA ≤ 1 32% (23/71) 13% 1.9 (1.4, 2.7) 0.0034
TJC28, SJC28, CRP, PtGA ≤ 1* 39% (23/59) 12% 2.4 (1.6,3.5) 0.0002
TJC28, SJC28, CRP, pain ≤ 1 34% (24/70) 13% 2.0 (1.4, 2.8) 0.0023
TJC28, SJC28, CRP, PhGA, PtGA ≤ 1 40% (22/55) 12% 2.6 (1.7, 3.8) 0.0002
TJC28, SJC28, CRP, PhGA, pain ≤ 1 38% (21/55) 13% 2.3 (1.6, 3.5) 0.0006
TJC28, SJC28, CRP, PtGA, pain ≤ 1 40% (21/53) 12% 2.6 (1.7, 3.9) 0.0002
TJC28, SJC28, CRP, PhGA, PtGA, pain ≤ 1 39% (20/51) 13% 2.5 (1.6, 3.9) 0.0005
Index-based definition
DAS28 < 2.6 25% (35/146) 11% 1.3 (1.1, 1.5) 0.0383
DAS28 < 2.0 28% (24/85) 12% 1.6 (1.2, 2.2) 0.0148
SDAI ≤ 3.3* 39% (27/69) 12% 2.3 (1.6, 3.2) 0.0001
Definitions without CRP (for clinical practice)
TJC28, SJC28, PhGA, PtGA ≤ 1 38% (23/60) 13% 2.3(1.6,3.4) 0.0003
TJC28, SJC28, PtGA < 1* 37% (24/65) 12% 2.0(1.4,2.9) 0.0004
CDAI ≤ 2.8* 36% (26/72) 12% 2.0(1.5,2.8) 0.0005
  1. *Average values calculated from the 500 bootstrap samples of patients not in remission.
  2. **Good outcome defined in a person when they had both good function and good radiographic outcomes (see Methods). CDAI: clinical disease activity index; CRP: C-reactive protein; DAS: disease activity score; EULAR: European League Against Rheumatism; PtGA: patient global assessment; PhGA: physician global assessment; RA: rheumatoid arthritis; SJC28: 28 swollen joint count; TJC28: 28 tender joint count.