Figure 4From: A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosusInhibition test and epitope mapping. (A) Inhibition tests of binding activities to HUVECs were performed by using IgG from healthy donor (control) and anti-FLRT2 sera (X10-48) with soluble FLRT2 at the indicated concentrations. (B) Changes in binding activity to FLRT2 lacking the unique region (Δur) compared with native FLRT2 were analyzed by using anti-FLRT2 sera. Representative dot plot (left) and a summary of changes in each patient (right) are shown. Open circles show the binding activity to the intracellular FLRT2 domain.Back to article page