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Figure 7 | Arthritis Research & Therapy

Figure 7

From: A novel autoantibody against fibronectin leucine-rich transmembrane protein 2 expressed on the endothelial cell surface identified by retroviral vector system in systemic lupus erythematosus

Figure 7

Activation of HUVECs and induction of apoptosis. (A) Expression of E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) was analyzed with flow cytometry against HUVECs treated with 640 μg/ml of control and two anti-FLRT2-positive IgGs, B11-8 and X10-48. Representative graphs (left) and summarized graph (right) are shown. (B) HUVECs treated with control IgG and two anti-FLRT2-positive IgGs, B11-8 and X10-48, for 24 hours were stained with annexin V and 7-AAD and analyzed with flow cytometry. (Annexin V positive/7-AAD negative) cells were measured as apoptotic cells. Representative graphs (left) and summarized graph (right) are shown. Error bars indicate SD.

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Arthritis Research & Therapy

ISSN: 1478-6362

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