Table 1 Challenging cultured fibroblast-like synoviocytes (FLS) with IL-18 did not directly stimulate proliferation or expression of molecules propagating rheumatoid arthritis
From: Expression of interleukin-18 receptor in fibroblast-like synoviocytes
Parameter | Unit | No. of experiments (No. of patients) | Control FLS (mean ± SD) | FLS + IL-18 (mean ± SD |
|---|---|---|---|---|
Proliferation | Extinction | 18 (6) | 0.084 (0.029–0.172) | 0.085 (0.029–0.171) |
MMP-1 | ng/ml | 36 (20) | 3.3 (1.5–83.7) | 2.9 (1.5–84.4) |
MMP-3 | ng/ml | 22 (11) | 20.0 (1.8–78.1) | 18.8 (3.3–81.1) |
ICAM-1 | MFI | 33 (9) | 60.2 (12.2–186.7) | 66.5 (9.0–183.9) |
VCAM-1 | MFI | 33 (9) | 39.5 (1.3–90.7) | 39.4 (1.3–94.2) |
Prostaglandin E2 | pg/ml | 12 (6) | 311 (104–537) | 264 (73–451) |
Nitric oxide | μM | 18 (9) | 1.76 (1.15–3.11) | 1.15 (0.67–2.13)** |
IL-6 | pg/ml | 22 (11) | 104.0 (27.7–445.3) | 145.8 (9.4–577.2) |
IL-8 | pg/ml | 27 (9) | 691 (167–2016) | 503 (139–2351) |
GM-CSF | pg/ml | 20 (10) | 0.59 (0.22–8.31) | 0.92 (0.21–8.24) |