From: B lymphocyte-typing for prediction of clinical response to rituximab
Parameter | Responders | Non-responders | Pvalue |
---|---|---|---|
 | (n= 42) | (n= 10) |  |
Age in years, mean ± SE | 62.7 ± 1.9 | 60.8 ± 3.1 | NSa |
Female gender, percentage | 81.0 | 60.0 | NSb |
Disease duration in years, mean ± SE | 11.7 ± 1.3 | 16.2 ± 3.9 | NSa |
ESRc, mean ± SE | 39.2 ± 3.8 | 43.3 ± 11.8 | NSa |
DAS28-ESR, mean ± SE | 5.9 ± 0.2 | 4.9 ± 0.3 | 0.016a |
Lymphocytesd, mean ± SE | 2,138 ± 174 | 3,083 ± 23 | 0.0279a |
RF-positive, percentage | 90.8 | 100.0 | NSb |
ACPA-positive, percentage | 76.9 | 80.0 | NSb |
Double-seropositive, percentage | 71.8 | 80.0 | NSb |
Double-seronegative, percentage | 7.7 | 0.0 | NSb |
Concomitant MTX usage, percentage | 40.4 | 41.7 | NSb |
Previous sDMARD, mean ± SE | 2.6 ± 0.1 | 2.0 ± 0.3 | NSa |
Previous TNF inhibitors, mean ± SE | 1.1 ± 0.1 | 1.4 ± 0.4 | NSa |
No previous biologics, percentage | 24.3 | 11.1 | NSb |
One previous biologic, percentage | 43.2 | 55.6 | NSb |
Two previous biologics, percentage | 27.1 | 11.1 | NSb |
Three previous biologics, percentage | 5.4 | 22.2 | NSb |
Systemic steroids, percentage | 40.0 | 31.0 | NSb |