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Table 1 Potential mechanisms of resistance or of susceptibility to depletion by anti-CD20monoclonal antibodies

From: B-cell subpopulations in humans and their differential susceptibility to depletionwith anti-CD20 monoclonal antibodies

Depletion Mechanisms
B-cell and antigen related Lack of CD20 surface expression
  CD20 (antigen) modulation/endocytosis
  Lipid raft composition
  Expression of complement regulatory proteins
Immune host phenomena related FcγRIIIA polymorphisms
  FcγRIIB expression
  C1q polymorphisms
  Exhaustion of cytotoxic mechanisms (for example, complement)
  1. Mechanisms reviewed in [24, 28].