Depletion | Mechanisms |
---|---|
B-cell and antigen related | Lack of CD20 surface expression |
 | CD20 (antigen) modulation/endocytosis |
 | Lipid raft composition |
 | Expression of complement regulatory proteins |
Immune host phenomena related | FcγRIIIA polymorphisms |
 | FcγRIIB expression |
 | C1q polymorphisms |
 | Exhaustion of cytotoxic mechanisms (for example, complement) |