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Table 1 Potential mechanisms of resistance or of susceptibility to depletion by anti-CD20monoclonal antibodies

From: B-cell subpopulations in humans and their differential susceptibility to depletionwith anti-CD20 monoclonal antibodies

Depletion

Mechanisms

B-cell and antigen related

Lack of CD20 surface expression

 

CD20 (antigen) modulation/endocytosis

 

Lipid raft composition

 

Expression of complement regulatory proteins

Immune host phenomena related

FcγRIIIA polymorphisms

 

FcγRIIB expression

 

C1q polymorphisms

 

Exhaustion of cytotoxic mechanisms (for example, complement)

  1. Mechanisms reviewed in [24, 28].