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Table 3 Human conditions associated with altered CD19 expression

From: Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity

CD19 upregulation

CD19 downregulation

Systemic sclerosis (MFI)

SLE (MFI)

SLE (CD19high B cells)

CD19 deficiency

CVID, HIV (CD19high B cells)

Heterozygous mutation in CD19

BCR deficiency (CD19high B cells)

CD81 deficiency

 

Mutations in Bruton's tyrosine kinase

  1. BCR, B-cell receptor; CVID, common variable immunodeficiency; MFI, mean fluorescence intensity; SLE, systemic lupus erythematosus.