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Table 3 Human conditions associated with altered CD19 expression

From: Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity

CD19 upregulation CD19 downregulation
Systemic sclerosis (MFI) SLE (MFI)
SLE (CD19high B cells) CD19 deficiency
CVID, HIV (CD19high B cells) Heterozygous mutation in CD19
BCR deficiency (CD19high B cells) CD81 deficiency
  Mutations in Bruton's tyrosine kinase
  1. BCR, B-cell receptor; CVID, common variable immunodeficiency; MFI, mean fluorescence intensity; SLE, systemic lupus erythematosus.