From: Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity
CD19 upregulation | CD19 downregulation |
---|---|
Systemic sclerosis (MFI) | SLE (MFI) |
SLE (CD19high B cells) | CD19 deficiency |
CVID, HIV (CD19high B cells) | Heterozygous mutation in CD19 |
BCR deficiency (CD19high B cells) | CD81 deficiency |
 | Mutations in Bruton's tyrosine kinase |