Gene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis

Table 3 Effect of anti-NRP1^B treatment on joint inflammation and destruction in mice with collagen-induced arthritis

Values are the percentage of joints with normal appearance or exhibiting inflammation and cartilage/bone degradation graded as mild, moderate, or severe, as assessed by haematoxylin and eosin. The numbers of joints assessed were as follows: 57 in the phage-derived monoclonal antibody against neuropilin-1 (anti-NRP1^B)-treated group and 58 in the PBS-treated group.
† The absolute numbers of mice exhibiting normal, mild, moderate, and severe arthritis changes were compared, and significance versus untreated mice was analysed by chi-square test for trend.

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