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Table 1 Smoking,alcohol drinkingand antibody response following pneumococcal vaccination in entire study population/different groups

From: The effect of smoking and alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis

  All participants (I)
RA on MTX
(II)
RA on anti-TNF as monotheraphy
(III)
RA on anti-TNF+ MTX
(IV)
SpA on anti-TNF as monotherapy
(V)
SpA on anti-TNF+MTX
(VI)
SpA on NSAID/analgesics
Number of patients at vaccination 505 85 79 89 83 83 86
Females (%) 63 79 87 78 34 53 45
CRP g/L (mean) 6.7 8.9 9.4 5.9 2.9 5.1 7.7
ESR mm/h (mean) 21.5 28.3 28.6 24.4 11.7 15.3 ( 5 15.3 19.8
Current smokers (%) 17 19 19 18 12 24 12
Ex-smokers (%) 40 39 38 45 45 39 35
Ever-smokers (%) 57.4 56.5 57.0 65.2 55.4 60.2 44.2
Smoking pack-years; mean (SD) 19.4 (14) 22.0 (13) 21.0 (15) 20.4 (14) 16.0 (13) 19.4 (13) 16.8 (13)
Current alcohol drinking (g/week) mean (SD) 9.7 (9) 13.2 (11) 8.0 (9) 10.4 (13) 12.2 (12) 8.5 (8) 11.8 (9)
IgG at vaccination (g/L)(SD) 10.4 (2.7) 9.7 (2.5) 11.8 (3.3) 11.0 (3.3) 9.9 (1.9) 9.9 (2.2) 9.9 (2.1)
IgM at vaccination (g/L)(SD) 1.3 (0.8) 1.1 (0.6) 1.7 (1.0) 1.4 (0.7) 1.3 (0.8) 1.2 (0.7) 1.0 (0.6)
IgA at vaccination (g/L)(SD) 2.7 (1.2) 2.5 (1.0) 3.3 (1.4) 2.8 (1.2) 2.7 (1.1) 2.4 (1.1) 2.5 (1.1)
Immune response (IR) for 23F (mean) 1 3.5 2.5 3.4 2.2 4.8 3.0 6.6
Immune response (IR) 1 for 6B (mean) 2.3 1.8 2.7 1.6 3.1 1.8 3.3
Patients with protective antibody levels for both 23F and 6B 4-6 weeks after vaccination (%)(posIR) 2 32.9 21.2 36.7 15.7 50.6 20.5 47.7
  1. 1Immune response = ratio between post- and prevaccination antibody levels.
  2. 2 Positive immune response (posIR) was defined as IR ≥2.