Table 1 Smoking,alcohol drinkingand antibody response following pneumococcal vaccination in entire study population/different groups
All participants | (I) RA on MTX | (II) RA on anti-TNF as monotheraphy | (III) RA on anti-TNF+ MTX | (IV) SpA on anti-TNF as monotherapy | (V) SpA on anti-TNF+MTX | (VI) SpA on NSAID/analgesics | |
|---|---|---|---|---|---|---|---|
Number of patients at vaccination | 505 | 85 | 79 | 89 | 83 | 83 | 86 |
Females (%) | 63 | 79 | 87 | 78 | 34 | 53 | 45 |
CRP g/L (mean) | 6.7 | 8.9 | 9.4 | 5.9 | 2.9 | 5.1 | 7.7 |
ESR mm/h (mean) | 21.5 | 28.3 | 28.6 | 24.4 | 11.7 | 15.3 ( 5 15.3 | 19.8 |
Current smokers (%) | 17 | 19 | 19 | 18 | 12 | 24 | 12 |
Ex-smokers (%) | 40 | 39 | 38 | 45 | 45 | 39 | 35 |
Ever-smokers (%) | 57.4 | 56.5 | 57.0 | 65.2 | 55.4 | 60.2 | 44.2 |
Smoking pack-years; mean (SD) | 19.4 (14) | 22.0 (13) | 21.0 (15) | 20.4 (14) | 16.0 (13) | 19.4 (13) | 16.8 (13) |
Current alcohol drinking (g/week) mean (SD) | 9.7 (9) | 13.2 (11) | 8.0 (9) | 10.4 (13) | 12.2 (12) | 8.5 (8) | 11.8 (9) |
IgG at vaccination (g/L)(SD) | 10.4 (2.7) | 9.7 (2.5) | 11.8 (3.3) | 11.0 (3.3) | 9.9 (1.9) | 9.9 (2.2) | 9.9 (2.1) |
IgM at vaccination (g/L)(SD) | 1.3 (0.8) | 1.1 (0.6) | 1.7 (1.0) | 1.4 (0.7) | 1.3 (0.8) | 1.2 (0.7) | 1.0 (0.6) |
IgA at vaccination (g/L)(SD) | 2.7 (1.2) | 2.5 (1.0) | 3.3 (1.4) | 2.8 (1.2) | 2.7 (1.1) | 2.4 (1.1) | 2.5 (1.1) |
Immune response (IR) for 23F (mean) 1 | 3.5 | 2.5 | 3.4 | 2.2 | 4.8 | 3.0 | 6.6 |
Immune response (IR) 1 for 6B (mean) | 2.3 | 1.8 | 2.7 | 1.6 | 3.1 | 1.8 | 3.3 |
Patients with protective antibody levels for both 23F and 6B 4-6 weeks after vaccination (%)(posIR) 2 | 32.9 | 21.2 | 36.7 | 15.7 | 50.6 | 20.5 | 47.7 |