The effect of smoking and alcohol consumption on markers of systemic inflammation, immunoglobulin levels and immune response following pneumococcal vaccination in patients with arthritis

Table 3 Impact of smoking on positive immune response forpneumococcal serotypes(23F and 6B) in RA patients on methotrexate

	B	P-value	Exp(B)	95% CI
				Lower	Upper
Smoking (pack-years)	-0.07	0.046	0.93	0.86	0.99
Age (years)	-0.01	0.724	0.99	0.95	1.03
Gender	0.85	0.341	2.34	0.41	13.43
CRP	-0.03	0.639	0.98	0.88	1.08
SJC28*	-0.09	0.502	0.91	0.69	1.20
TJC28*	0.00	1.000	1.0	0.76	1.32
Pre-vaccination antibody levels for serotype 23F	-0.42	0.090	0.66	0.41	1.07
Smoking (ever)	-1.58	0.025	0.21	0.05	0.81

*swollen and tender joint count in 28-joint count index
Two different logistic regression models were created analyzing smoking (pack-years) and smoking (ever) variable, respectively adjusted for the same covariates.

ISSN: 1478-6362