Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

Table 1 AMD3100 reduced the levels of SDF-1, pro-MMP-1, MMP-13, and IL-1 in guinea pig synovial fluid and of IL-1 in guinea pig serum

	SDF-1, ng/ml	Pro-MMP-1, ng/ml	MMP-13, ng/ml	IL-1, ng/ml	IL-1 (serum), pg/ml
AMD3100	0.209 ± 0.023^a	2.350 ± 1.101^a	7.620 ± 0.399^a	1.108 ± 0.416^a	71.946 ± 40.491^a
Primary OA	0.340 ± 0.071	4.286 ± 1.173	8.771 ± 0.830	2.005 ± 0.521	137.857 ± 42.998
PBS	0.355 ± 0.079	4.459 ± 1.764	8.382 ± 1.041	1.782 ± 0.602	156.071 ± 35.557

Data are expressed as mean ± SD. AMD3100 (n = 13); primary OA, n = 11; PBS, n = 11. ^aP <0.05. The concentration of SDF-1, pro-MMP-1, and MMP-13 in the AMD3100-treated group was significantly lower than those of the primary OA group and the sham group. The high concentration of IL-1in synovial fluid and in serum was found in the primary OA and the PBS-treated groups, whereas blocking SDF-1/CXCR4 by AMD3100 significantly decreased the level of IL-1 in the AMD3100-treated animals.

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