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Figure 1 | Arthritis Research & Therapy

Figure 1

From: IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro

Figure 1

Study design. After fabrication, microsphere morphology was examined qualitatively by means of scanning electron microscopy. Interleukin-1 receptor antagonist (IL-1ra) release kinetics were quantified. IL-1ra conditioned media were generated by suspending microspheres in CM- (chemically defined medium without transforming growth factor-beta 3) under gentle agitation. Media containing released IL-1ra were collected at the intervals indicated and used to treat functionally mature nucleus pulposus (NP) constructs that were challenged with IL-1β.

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Arthritis Research & Therapy

ISSN: 1478-6362

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