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Genes that change only in response to hypoxia
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Genes that change only in response to DMOG
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Genes that change in response to hypoxia and DMOG
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|---|
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TGF-β1 (2*)
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NRP2 (-2*)
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VEGF (8*/31*)
|
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HPSE (-2*)
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ID3 (-3*)
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PLAU (-2*/-2*)
|
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FIGF (-2*)
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EFNB2 (5*)
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LEP (108***/85***)
|
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CXCL-5 (-2*)
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CCL2 (-4*)
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HIF1A (-2*/-2*)
|
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CCL-11 (-9*)
| |
HAND2 (-2*/-6*)
|
| | |
EFNA3 (2*/9*)
|
| | |
ANGPTL4 (12**/48**)
|
- Genes significantly upregulated or downregulated by a factor ≥2. Genes from Figure 1b,c that change following 24 hours of hypoxia and in response to stimulation with the hypoxia-inducible factor activator dimethyloxalylglycine (DMOG) in rheumatoid arthritis fibroblast-like synoviocytes from five and three patients, respectively. Data presented as mean fold-change. Genes that changed significantly (P < 0.05) by a factor ≥2-fold were analysed by paired Student's t test comparing ΔCt values: *P < 0.05, **P < 0.001, ***P < 0.001. ANGPTL, angiopoietin-like; EFNA3, ephrin A3;EFNB2, ephrin B2; FIGF, C-fos-induced growth factor (VEGF D); HAND2, Heart and neural crest derivatives expressed 2; HPSE, heparanase; ID3, inhibitor of DNA-binding 3, dominant negative helix-loop-helix protein; LEP, leptin; NRP2, neuropillin 2; PLAU, plasminogen activator urokinase; TGF, transforming growth factor; VEGF, vascular endothelial growth factor.
