TY - JOUR AU - Perl, A. PY - 2010 DA - 2010// TI - Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment JO - Autoimmunity VL - 43 UR - https://doi.org/10.3109/08916930903374774 DO - 10.3109/08916930903374774 ID - Perl2010 ER - TY - JOUR AU - Fernandez, D. R. AU - Perl, A. PY - 2010 DA - 2010// TI - mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? JO - Discov Med VL - 9 ID - Fernandez2010 ER - TY - JOUR AU - Fernandez, D. R. AU - Telarico, T. AU - Bonilla, E. AU - Li, Q. AU - Banerjee, S. AU - Middleton, F. A. AU - Phillips, P. E. AU - Crow, M. K. AU - Oess, S. AU - Muller-Esterl, W. AU - Perl, A. PY - 2009 DA - 2009// TI - Activation of mTOR controls the loss of TCR in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation JO - J Immunol VL - 182 UR - https://doi.org/10.4049/jimmunol.0803600 DO - 10.4049/jimmunol.0803600 ID - Fernandez2009 ER - TY - STD TI - Lai Z, Telarico T, Bartos A, Miklossy G, Hanczko R, Jimah J, Clair B, Tily H, Francis L, Garcia R, Phillips PE, Ramos I, Perl A: Reversal of CD3/CD4/CD25/Foxp3 Treg depletion in active SLE patients with rapamycin. Arthritis Rheum. 2010, 1196-doi: 10.1002/art.28951, Suppl 10 ID - ref4 ER - TY - JOUR AU - Francis, L. AU - Perl, A. PY - 2009 DA - 2009// TI - Pharmacotherapy of systemic lupus erythematosus JO - Expert Opin Pharmacother VL - 10 UR - https://doi.org/10.1517/14656560902971003 DO - 10.1517/14656560902971003 ID - Francis2009 ER - TY - CHAP AU - Lai, Z. -. W. AU - Hanczko, R. AU - Bonilla, E. AU - Caza, T. N. AU - Clair, B. AU - Bartos, A. AU - Miklossy, G. AU - Jimah, J. AU - Doherty, E. AU - Tily, H. AU - Francis, L. AU - Garcia, R. AU - Dawood, M. AU - Yu, J. AU - Ramos, I. AU - Coman, I. AU - Faraone, S. V. AU - Phillips, P. E. AU - Perl, A. PY - 2012 DA - 2012// TI - N-acetylcysteine reduces disease activity by blocking mTOR in T cells of lupus patients BT - Arthritis Rheum ID - Lai2012 ER - TY - JOUR AU - Fernandez, D. AU - Bonilla, E. AU - Mirza, N. AU - Perl, A. PY - 2006 DA - 2006// TI - Rapamycin reduces disease activity and normalizes T-cell activation-induced calcium fluxing in patients with systemic lupus erythematosus JO - Arthritis Rheum VL - 54 UR - https://doi.org/10.1002/art.22085 DO - 10.1002/art.22085 ID - Fernandez2006 ER -