Table 1 Frequency of FH-autoantibodies and CFHR1 deficiency in patients compared to healthy controls.
Total number of patients and controls | FH-autoantibody positive individuals | FH-autoantibody negative individuals | Odds Ratio for anti-FH positivity in CFHR1 deficiency | ||||||
|---|---|---|---|---|---|---|---|---|---|
% | No. | CFHR1 deficiency No. (%) | No. | CFHR1 deficiency No. (%) | OR | 95% CI | P-value | ||
LA+ Sweden | 64 | 9.4 | 6 | 5 (83.3) | 58 | 1 (1.7) | 285 | 15.4 to 5,280 | <0.0001 |
Controls Sweden | 64 | 6.3 | 4 | 1 (25.0) | 60 | 1 (1.7) | 20 | 1.0 to 397 | 1.12 |
SLE Low SLEDAI, Sweden | 30 | 0.0 | 0 | 0 (0.0) | 30 | 1 (3.3) | n.a1 | ||
Controls Sweden | 30 | 0.0 | 0 | 0 (0.0) | 30 | 0 (0.0) | n.a. | ||
SLE High SLEDAI, Sweden | 30 | 13.3 | 4 | 0 (0.0) | 26 | 1 (3.8) | 2.0 | 0.066 to 54.1 | 1 |
Controls Sweden | 30 | 10.0 | 3 | 0 (0.0) | 27 | 1 (3.7) | 6.3 | 0.17 to 231 | 1 |
RA Sweden | 97 | 16.5 | 16 | 2 (12.5) | 81 | 5 (6.2) | 2.0 | 0.38 to12.3 | 0.3 |
Controls Sweden | 97 | 2.1 | 2 | 0(0.0) | 95 | 1(1.1) | 12.3 | 0.44 to 384 | 1 |
RA The Netherlands | 217 | 9.2 | 20 | 0 (0.0) | 197 | 7 (3.6) | n.a. | ||
Controls The Netherlands | 161 | 3.1 | 5 | 0 (0.0) | 156 | 13 (8.3) | n.a. | ||
aHUS Germany | 103 | 11.7 | 12 | 3 (25.0) | 91 | 4 (4.4) | 6.45 | 1.25 to 33.05 | 0.04 |
Controls Germany | 20 | 5.0 | 1 | 0 (0.0) | 19 | 0 (0.0) | n.a. | ||