Table 3 Clinical outcomes by age at menopause
From: Early menopause and severity of rheumatoid arthritis in women older than 45 years
Early menopause (< 46 years) (n= 25) a | Normal/late menopause (≥ 46 years) (n= 102) a | |
|---|---|---|
Mean age at diagnosis; years (SD) | 65.2 (6.94) | 62.8 (8.48) |
Mean follow-up time; years (SD) | 10.5 (3.0) | 10.1 (3.6) |
> 3 DMARDs used (%) | 5/25 (20.0) | 23/101 (22.8) |
DMARDs in combination (%) | 8/25 (32.0) | 45/101 (44.6) |
Biological treatment ever (%) | 3/25 (12.0) | 33/101 (32.7) |
Documented radiographic erosions (ever) (%) | 14/23 (60.9) | 52/96 (54.2) |
RF positive (%) | 11/25 (44.0) | 78/100 (78.0) |
Mean HAQ at diagnosis (CI)b | 0.58 (0.22-0.93) (n = 12) | 0.96 (0.79-1.12) (n = 55) |
Mean HAQ 1 year after diagnosis (CI)b | 0.45 (0.08-0.83) (n = 12) | 0.86 (0.70-1.02) (n = 65) |
Mean HAQ 5 years after diagnosis (CI)b | 0.88 (0.60-1.15) (n = 19) | 0.90 (0.76-1.05) (n = 68) |
Mean HAQ 10 years after diagnosis (CI)b | 0.67 (0.34-1.00) (n = 12) | 0.98 (0.82-1.14) (n = 49) |
Cluster distribution (P = 0.005) | ||
Severe RA (%) | 3 (15.8%) | 23 (34.8%) |
Mild/moderate seropos RA (%) | 5 (26.3%) | 30 (45.5%) |
Mild/moderate seroneg RA (%) | 11 (57.9%) | 13 (19.7%) |