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Table 3 Clinical outcomes by age at menopause

From: Early menopause and severity of rheumatoid arthritis in women older than 45 years

  Early menopause
(< 46 years) (n= 25) a
Normal/late menopause
(≥ 46 years) (n= 102) a
Mean age at diagnosis; years (SD) 65.2 (6.94) 62.8 (8.48)
Mean follow-up time; years (SD) 10.5 (3.0) 10.1 (3.6)
> 3 DMARDs used (%) 5/25 (20.0) 23/101 (22.8)
DMARDs in combination (%) 8/25 (32.0) 45/101 (44.6)
Biological treatment ever (%) 3/25 (12.0) 33/101 (32.7)
Documented radiographic erosions (ever) (%) 14/23 (60.9) 52/96 (54.2)
RF positive (%) 11/25 (44.0) 78/100 (78.0)
Mean HAQ at diagnosis (CI)b 0.58 (0.22-0.93) (n = 12) 0.96 (0.79-1.12) (n = 55)
Mean HAQ 1 year after diagnosis (CI)b 0.45 (0.08-0.83) (n = 12) 0.86 (0.70-1.02) (n = 65)
Mean HAQ 5 years after diagnosis (CI)b 0.88 (0.60-1.15) (n = 19) 0.90 (0.76-1.05) (n = 68)
Mean HAQ 10 years after diagnosis (CI)b 0.67 (0.34-1.00) (n = 12) 0.98 (0.82-1.14) (n = 49)
Cluster distribution (P = 0.005)   
   Severe RA (%) 3 (15.8%) 23 (34.8%)
   Mild/moderate seropos RA (%) 5 (26.3%) 30 (45.5%)
   Mild/moderate seroneg RA (%) 11 (57.9%) 13 (19.7%)
  1. CI, confidence Interval; HAQ, Health Assessment Questionnaire; RF, rheumatoid factor; SD, standard deviation. aIn case of missing data, numbers (n) indicated for each variable. bAdjusted for age at diagnosis.