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Table 1 Differential diagnosis of idiopathic CD4 lymphocytopenia

From: Idiopathic CD4 lymphocytopenia: a case of missing, wandering or ineffective T cells

Infections HIV1,2
  HTLV1, 2
  Mycobacterial infections
  EBV, CMV
Malignancies/hematologic conditions Lymphoma
  Aplastic anemia
  Myelodysplastic syndrome
Autoimmune Systemic lupus erythematosus
  Sjögren's syndrome
  Kikuchi disease
Medications Chemotherapy and immunosuppressants
  Corticosteroids
Genetic syndromes XMEN
  WHIM
  Unc119 mutation
Various Sarcoidosis
  Common variable immunodeficiency
  1. CMV, cytomegalovirus; EBV, Epstein-Barr virus; Unc119, Uncoordinated 119; WHIM, warts, hypogammaglobulinemia, infections, and myelokathexis; XMEN, X-linked magnesium deficiency with Epstein-Barr virus and neoplasia.