Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study

Seymour, Matthew W; Kelly, Stephen; Beals, Chan R; Malice, Marie-Pierre; Bolognese, James A; Dardzinski, Bernard J; Cheng, Amy S; Cummings, Corinne E; Smugar, Steven S; McClinton, Catherine; Fox, Amy; Dooley, William M; Pitzalis, Constantino; Taylor, Peter C

doi:10.1186/ar4034

Table 3 Reproducibility of US endpoints.

From: Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study

10 MCP US endpoint	Reproducibility method	Baseline ICC (95% CI)	Day 15 ICC (95% CI)
Long PDA	Within-scan inter-reader	0.89 (0.80; 0.99)	0.98 (0.95; 1.00)
	Parallel scan intra-reader	0.80 (0.64; 0.96)	0.62 (0.36; 0.88)
	Parallel scan inter-reader	0.78 (0.59; 0.97)	0.68 (0.45; 0.92)
Long STA	Within-scan inter-reader	0.76(0.56; 0.95)	0.81 (0.65; 0.97)
	Parallel scan intra-reader	0.95 (0.90; 1.00)	0.83 0.68; 0.98)
	Parallel scan inter-reader	0.85 (0.72; 0.98)	0.71 (0.48; 0.95)
Long STi	Within-scan inter-reader	0.67 (0.40; 0.93)	0.54 (0.20; 0.88)
	Parallel scan intra-reader	0.87 (0.75; 0.99)	0.82 (0.66; 0.98)
	Parallel scan inter-reader	0.67 (0.42; 0.93)	0.46 (0.07; 0.85)
Long VASCi	Within-scan inter-reader	0.90 (0.81; 0.99)	0.94 (0.88; 1.00)
	Parallel scan intra-reader	0.93 (0.87; 0.99)	0.94 (0.88; 1.00)
	Parallel scan inter-reader	0.83 (0.67; 0.98)	0.85 (0.72; 0.99)
Trans PDA	Within-scan inter-reader	0.99 (0.98; 1.00)	1.00 (0.99; 1.00)
	Parallel scan intra-reader	0.75 (0.57; 0.93)	0.76 (0.57; 0.94)
	Parallel scan inter-reader	0.72 (0.51; 0.93)	0.75 (0.55; 0.96)
Trans STA	Within-scan inter-reader	0.52 (0.33; 0.72)	0.57 (0.36; 0.79)
	Parallel scan intra-reader	0.83 (0.68; 0.98)	0.92 (0.85; 0.99)
	Parallel scan inter-reader	0.57 (0.24; 0.89)	0.40 (0.01; 0.80)
Trans STi	Within-scan inter-reader	0.48 (0.19; 0.76)	0.36 (0.10; 0.62)
	Parallel scan intra-reader	0.83 (0.68; 0.98)	0.77 (0.58; 0.97)
	Parallel scan inter-reader	0.00 (-0.46; 0.46)	0.01 (-0.46; 0.48)
Trans VASCi	Within-scan inter-reader	0.92 (0.84; 0.99)	0.96 (0.92; 1.00)
	Parallel scan intra-reader	0.73 (0.52; 0.94)	0.91 (0.84; 0.99)
	Parallel scan inter-reader	0.68 (0.45; 0.92)	0.78 (0.60; 0.96)

ICC (intraclass correlation coefficient) values of <0.40, poor to fair agreement; 0.41 to 0.60, moderate agreement; 0.61 to 0.80, good agreement; and 0.81 to 1.00, excellent agreement. CI, confidence interval; PDA; Power Doppler Area; STA, synovial thickness area; STi, synovial thickness index; VASCi, vascularity index.

Back to article page

ISSN: 1478-6362

Contact us

General enquiries: journalsubmissions@springernature.com

Arthritis Research & Therapy

Contact us