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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells

Figure 2

Production of TNF-α by spleen CD4+ T cells after anti-CD4 preincubation, as measured by bioassay (means ± SEM of three experiments; pooled T cells from three normal rats each). The accelerating mAb, RIB5/2, induced a significantly stronger increase of secreted TNF-α than the other mAbs. Specificity was ensured by adding a neutralizing anti-TNF-α mAb to supernatants from RIB5/2-treated cultures. *P ≤ 0.05 in comparison with the isotype control, #P ≤ 0.05 in comparison with W3/25, §P ≤ 0.05 in comparison with OX35.

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