MMP2
|
20.24
|
17
|
36.4
|
[P08253]
|
72 kDa type IV collagenase
|
Angiogenesis/collagen degradation
| |
x
|
A1AT
|
2
|
2
|
6
|
[P01009]
|
Alpha-1-antitrypsin
|
Inhibitor of serine proteases
| | |
ANXA2
|
2
|
1
|
36
|
[P07355]
|
Annexin A2
|
Heat-stress response
| | |
B2MG
|
4
|
3
|
26.9
|
[P61769]
|
Beta-2-microglobulin
|
Immunity
|
x
| |
PGS1
|
4.03
|
3
|
13.9
|
[P21810]
|
Biglycan
|
Collagen fiber assembly/ECM component
| | |
CATB
|
3.06
|
2
|
15.3
|
[P07858]
|
Cathepsin B
|
Thiol protease
| | |
CCL2
|
6
|
4
|
38.4
|
[P13500]
|
C-C motif chemokine 2b
|
Inflammatory response
| | |
CCL8
|
4
|
2
|
38.4
|
[P80075]
|
C-C motif chemokine 8b
|
Inflammatory response
| | |
CH3L1
|
63.26
|
96
|
82
|
[P36222]
|
Chitinase-3-like protein 1
|
ECM component
| |
x
|
CH3L2
|
2
|
2
|
17.7
|
[Q15782]
|
Chitinase-3-like protein 2b
|
ECM component
| | |
CLUS
|
10.09
|
9
|
43.2
|
[P10909]
|
Clusterin
|
Immunity
|
x
|
x
|
CCD80
|
2
|
1
|
23.3
|
[Q76M96]
|
Coiled-coil domain-containing protein 80
|
Cell adhesion and matrix assembly
| | |
CO3A1
|
2.02
|
1
|
14.3
|
[P02461]
|
Collagen alpha-1(III) chain
|
ECM component
| | |
CO6A1
|
4.16
|
4
|
28.5
|
[P12109]
|
Collagen alpha-1(VI) chain
|
ECM component
| | |
COCA1
|
17.35
|
10
|
21.1
|
[Q99715]
|
Collagen alpha-1(XII) chain
|
ECM component
| | |
CO1A2
|
27.65
|
25
|
55.2
|
[P08123]
|
Collagen alpha-2(I) chain
|
ECM component
| | |
C1R
|
8.13
|
7
|
31.5
|
[P00736]
|
Complement C1r subcomponent
|
Immunity
|
x
|
x
|
C1S
|
10.6
|
9
|
27.3
|
[P09871]
|
Complement C1s subcomponent
|
Immunity
|
x
|
x
|
CO3
|
13.4
|
7
|
26.4
|
[P01024]
|
Complement C3
|
Immunity
|
x
| |
CFAB
|
8.29
|
6
|
17.2
|
[P00751]
|
Complement factor B
|
Immunity
|
x
|
x
|
CXCL3
|
4.01
|
4
|
69.2
|
[P19876]
|
C-X-C motif chemokine 3b
|
inflammatory response
| | |
CXCL5
|
2
|
1
|
20.2
|
[P42830]
|
C-X-C motif chemokine 5b
|
Inflammatory response
| | |
CXCL6
|
4.13
|
5
|
38.6
|
[P80162]
|
C-X-C motif chemokine 6b
|
Inflammatory response
| | |
CYTC
|
4
|
3
|
67.1
|
[P01034]
|
Cystatin-C
|
Inhibitor of cysteine proteinases
|
x
| |
PGS2
|
23.72
|
22
|
56
|
[P07585]
|
Decorin
|
ECM component
| | |
DESP
|
2
|
1
|
24.8
|
[P15924]
|
Desmoplakinb
|
Cell junction
|
x
| |
FBLN3
|
15.7
|
12
|
31.2
|
[Q12805]
|
EGF-containing fibulin-like extracellular matrix protein 1
|
Negative regulator of chondrocyte differentiation
|
x
|
x
|
FINC
|
152.34
|
150
|
58.9
|
[P02751]
|
Fibronectin
|
ECM component
|
x
|
x
|
FBLN1
|
2
|
1
|
11.2
|
[P23142]
|
Fibulin-1
|
Cell adhesion/ECM organization
|
x
| |
FSTL1
|
2.1
|
2
|
16.2
|
[Q12841]
|
Follistatin-related protein 1
|
Cell proliferation and differentiation
| | |
GDN
|
24.73
|
23
|
54.5
|
[P07093]
|
Glia-derived nexin
|
Serine protease inhibitor
| | |
GROA
|
4
|
5
|
54.2
|
[P09341]
|
Growth-regulated alpha protein
|
Inflammatory response
| | |
IBP3
|
12.02
|
12
|
57.7
|
[P17936]
|
Insulin-like growth factor-binding protein 3
|
Cell proliferation and differentiation
|
x
| |
IBP4
|
3.36
|
3
|
37.6
|
[P22692]
|
Insulin-like growth factor-binding protein 4
|
Cell proliferation and differentiation
| | |
IBP5
|
4.03
|
2
|
55.5
|
[P24593]
|
Insulin-like growth factor-binding protein 5
|
Cell proliferation and differentiation
| | |
IBP6
|
3.85
|
3
|
43.8
|
[P24592]
|
Insulin-like growth factor-binding protein 6
|
Cell proliferation and differentiation
|
x
| |
IBP7
|
2.15
|
3
|
29.1
|
[Q16270]
|
Insulin-like growth factor-binding protein 7
|
Cell proliferation and differentiation
| | |
IL6
|
16
|
16
|
42
|
[P05231]
|
IL-6
|
Inflammatory response
| | |
IL8
|
4.24
|
6
|
57.6
|
[P10145]
|
IL-8
|
Inflammatory response
| | |
MMP1
|
35.12
|
38
|
50.1
|
[P03956]
|
Interstitial collagenase
|
Collagen degradation
| | |
K1C10
|
60.82
|
36
|
66.8
|
[P13645]
|
Keratin, type I cytoskeletal 10
|
Intermediate filament
|
x
|
x
|
K1C14
|
11.36
|
7
|
44.9
|
[P02533]
|
Keratin, type I cytoskeletal 14b
|
Intermediate filament
| | |
K1C16
|
15.45
|
8
|
48
|
[P08779]
|
Keratin, type I cytoskeletal 16b
|
Intermediate filament
| | |
K1C9
|
30.98
|
19
|
60.2
|
[P35527]
|
Keratin, type I cytoskeletal 9
|
Intermediate filament
|
x
|
x
|
K2C1
|
70.89
|
41
|
69.6
|
[P04264]
|
Keratin, type II cytoskeletal 1
|
Intermediate filament
|
x
|
x
|
K22E
|
43.26
|
22
|
69.2
|
[P35908]
|
Keratin, type II cytoskeletal 2 epidermal
|
Intermediate filament
|
x
|
x
|
K2C6B
|
20.77
|
11
|
53.9
|
[P04259]
|
Keratin, type II cytoskeletal 6Bb
|
Intermediate filament
| |
x
|
MFGM
|
6.01
|
4
|
20.9
|
[Q08431]
|
Lactadherin
|
Angiogenesis
| | |
LUM
|
28.15
|
30
|
60.7
|
[P51884]
|
Lumican
|
ECM component
|
x
|
x
|
CSF1
|
4.01
|
2
|
17.3
|
[P09603]
|
Macrophage colony-stimulating factor 1b
|
Inflammatory response
| | |
TIMP1
|
17.8
|
16
|
57.5
|
[P01033]
|
Metalloproteinase inhibitor 1
|
Metalloprotease inhibitor
| |
x
|
TIMP2
|
4
|
3
|
32.7
|
[P16035]
|
Metalloproteinase inhibitor 2
|
Metalloprotease inhibitor
| | |
PTX3
|
2.02
|
2
|
14.4
|
[P26022]
|
Pentraxin-related protein PTX3
|
Inflammatory response
| | |
PLTP
|
5.8
|
4
|
31
|
[P55058]
|
Phospholipid transfer protein
|
Lipid transport
|
x
|
x
|
IC1
|
4
|
2
|
18.8
|
[P05155]
|
Plasma protease C1 inhibitor
|
Immunity
|
x
|
x
|
POTEF
|
2.03
|
1
|
27.6
|
[A5A3E0]
|
POTE ankyrin domain family member Fb
|
Unknown
| | |
SAP
|
2
|
1
|
5
|
[P07602]
|
Proactivator polypeptideb
|
Lipid metabolism
| | |
PCOC1
|
5.93
|
4
|
19.8
|
[Q15113]
|
Procollagen C-endopeptidase enhancer 1
|
Collagen metabolism
| |
x
|
S10A8
|
1.54
|
1
|
35.5
|
[P05109]
|
Protein S100-A8b
|
Inflammatory response
|
x
| |
S10A9
|
4
|
2
|
34.2
|
[P06702]
|
Protein S100-A9b
|
Inflammatory response
|
x
| |
PRG4
|
3.7
|
3
|
21.9
|
[Q92954]
|
Proteoglycan 4b
|
ECM component
|
x
|
x
|
TRY6
|
4
|
2
|
15.4
|
[Q8NHM4]
|
Putative trypsin-6b
|
Serine protease
| | |
NPT2C
|
2
|
1
|
10.9
|
[Q8N130]
|
Sodium-dependent phosphate transport protein 2Cb
|
Ion transport
| | |
SPRC
|
2
|
2
|
7.3
|
[P09486]
|
SPARC
|
Cell proliferation and differentiation
|
x
| |
MMP3
|
48.64
|
47
|
71.9
|
[P08254]
|
Stromelysin-1
|
Collagen degradation
| |
x
|
QSOX1
|
4.87
|
4
|
16.3
|
[O00391]
|
Sulfhydryl oxidase 1
|
Cell redox homeostasis
|
x
| |
SDC4
|
2
|
1
|
13.6
|
[P31431]
|
Syndecan-4
|
ECM component
| | |
TARSH
|
8.86
|
9
|
27.4
|
[Q7Z7G0]
|
Target of Nesh-SH3
|
Cell proliferation and differentiation
|
x
| |
TENA
|
13.36
|
8
|
22.5
|
[P24821]
|
Tenascin
|
Cell adhesion/ECM organization
| | |
TETN
|
4
|
4
|
34.2
|
[P05452]
|
Tetranectin
|
Bone mineralization
|
x
|
x
|
TSP1
|
2.36
|
2
|
18.5
|
[P07996]
|
Thrombospondin-1
|
Angiogenesis
|
x
| |
BGH3
|
2
|
1
|
22.6
|
[Q15582]
|
TGF-beta-induced protein ig-h3
|
TGF-beta signaling
|
x
| |
TSG6
|
28.35
|
30
|
69.3
|
[P98066]
|
TNF-inducible gene 6 protein
|
Cell adhesion
| | |
VCAM1
|
2
|
1
|
12.2
|
[P19320]
|
Vascular cell adhesion protein 1
|
Cell adhesion
|
x
| |
VASN
|
2
|
2
|
14.7
|
[Q6EMK4]
|
Vasorin
|
TGF-beta signaling
|
x
| |