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Table 2 Extracellular proteins modulated by chondroitin sulfate treatment in IL-1β-stimulated chondrocytes

From: Secretome analysis of chondroitin sulfate-treated chondrocytes reveals anti-angiogenic, anti-inflammatory and anti-catabolic properties

Accession numbera Name Symbol Ratiob Pvalue Error factorc
[P00751] Complement factor B CFAB 0.5566 0.0064 1.397
[Q08431] Lactadherin MFGM 0.597 0.0151 1.3855
[Q7Z7G0] Target of Nesh-SH3 TARSH 0.7017 0.006 1.2209
[P09871] Complement C1s subcomponent C1S 0.7085 0.0007 1.1398
[P01024] Complement C3 CO3 0.7241 0.0023 1.1999
[P02751] Fibronectin FINC 0.7321 0.0006 1.1891
[P03956] Interstitial collagenase MMP1 0.7113 0 1.0977
[P00736] Complement C1r subcomponent C1R 0.7734 0.0071 1.1755
[P08253] 72 kDa type IV collagenase MMP2 0.7759 0.0001 1.0999
[P36222] Chitinase-3-like protein 1 CH3L1 0.8088 0.0216 1.4096
[P10909] Clusterin CLUS 0.8224 0.05 1.2162
[P08254] Stromelysin-1 MMP3 0.8256 0.0086 1.1378
[P07093] Glia-derived nexin GDN 1.2894 0.0031 1.1664
[O00391] Sulfhydryl oxidase 1 QSOX1 1.3064 0.0382 1.2709
[Q92954] Proteoglycan 4 PRG4 1.4393 0.05 1.445
[P98066] TNF-inducible gene 6 protein TSG6 1.7773 0.0007 1.3371
[P61769] Beta-2-microglobulin B2MG 2.1652 0.0125 1.4553
[P07996] Thrombospondin-1 TSP1 89.1678 0 >2
  1. Extracellular proteins identified by SILAC and liquid chromatography-mass spectrometry analysis as modulated by CS treatment in IL-1β-stimulated chondrocytes. aProtein accession number according to the SwissProt and TrEMBL databases. bAverage SILAC ratios (n = 3) that represent the relative protein abundance in CS-treated versus untreated cells, calculated by Protein Pilot 3.0 software (ABSciex). P ≤ 0.05 was accepted. cError factor of the quantification (measure of the error in the average quantification ratio as calculated by Protein Pilot 3.0 software).