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Table 6 Multivariate baseline predictors of mortality due to pneumonia and mortality due to other respiratory diseases in rheumatoid arthritis patients

From: Association of circulating levels of MMP-8 with mortality from respiratory disease in patients with rheumatoid arthritis

Step and variable Hazard ratio (95% CI) P
Mortality due to pneumonia   
1. Age 1.08/yr (1.05, 1.17) < 0.0001
2. MMP-8 (ng/ml) 1.012 (1.010, 1.025) 0.0002
3. Nodular disease 2.36 (1.01, 5.53) 0.01
4. Rheumatoid factor 2.66 (1.03, 6.82) 0.05
Mortality due to other respiratory diseases*   
1. Age 1.09/yr (1.03, 1.16) 0.006
2. Nodular disease 4.45 (1.55, 12.81) 0.006
3. MMP-8 (ng/ml) 1.016 (1.004, 1.03) 0.004
  1. Stepwise Cox proportional hazards regression. Baseline variables included in the analyses were age, sex, disease duration, metalloproteinase (MMP)-8 (ng/ml), rheumatoid factor (+/-), nodular disease (+/-), C-reactive protein (mg/dl), erythrocyte sedimentation rate (mm/h), Health Assessment Questionnaire (score 0 to 3), Larsen score, taking drugs for cardiovascular disease (CVD) (+/-) and smoking at entry (+/-). Only significant variables retained in the stepwise analysis are shown. *Includes pulmonary fibrosis (n = 3), chronic obstructive pulmonary disease (n = 4), bronchitis (n = 2), bronchiectasis (n = 3) and asthma (n = 1).