Figure 2From: Tissue factor as a proinflammatory agentMorphological changes in the joint after injection of TF. (a) Histopathology of an arthritic knee joint four days after injection of TF (20 μg/joint). Infiltration of mononuclear cells in synovial tissue is apparent. Original magnification ×20. (b) Immunohistochemical staining of an arthritic knee joint, showing cells expressing Mac-1. Original magnification ×40. JC, joint cavity; C, cartilage; SH, synovial hyperplasy; P, pannus; Er, bone erosion; ST, synovial tissue. Arrows indicate inflammatory cells in synovia, pannus formation and cartilage destruction.Back to article page