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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Tissue factor as a proinflammatory agent

Figure 2

Morphological changes in the joint after injection of TF. (a) Histopathology of an arthritic knee joint four days after injection of TF (20 μg/joint). Infiltration of mononuclear cells in synovial tissue is apparent. Original magnification ×20. (b) Immunohistochemical staining of an arthritic knee joint, showing cells expressing Mac-1. Original magnification ×40. JC, joint cavity; C, cartilage; SH, synovial hyperplasy; P, pannus; Er, bone erosion; ST, synovial tissue. Arrows indicate inflammatory cells in synovia, pannus formation and cartilage destruction.

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