Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

Table 2 Relation of CRP genotypes to baseline CRP levels

SNP	HWE (p)	Genotype	Geometric mean CRP (mg/L) (SD)	n	Pvalue
rs1205	0.60	GG	32.17 (2.75)	272	Ref.
		GA	31.51 (2.67)	270	0.81
		AA	26.39 (2.70)	57	0.17
rs1800947†	0.23	CC	31.93 (2.70)	533	Ref.
		CG	26.47 (2.76)	66	0.15
rs3091244_T	0.33‡	XX	29.09 (2.73)	278	Ref.
		XT	34.40 (2.72)	261	0.05
		TT	28.94 (2.53)	60	0.97
rs3091244_A¶		XX	31.36 (2.70)	550	Ref.
		XA	30.32 (2.68)	33	0.85

SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg Expectation; SD, standard copies of T allele. For the A allele of rs3091244: XX, no copies of A allele; XA one copy of A allele; AA two copies of A allele.
† No homozygote minor allele observed in this dataset.
‡ rs3091244_T & rs3091244_A SNPs combined to give HWE of rs3091244.
¶ Homozygote minor alleles grouped with heterozygotes.

ISSN: 1478-6362