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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

Figure 4

Effects of glucocorticoids or TNFα on Wnt-related gene expression. (A and B) Effect of glucocorticoid treatment (100 nM dexamethasone) or TNFα (10 ng/ml) on expression of Wnt-related genes (n = 96) was examined using a targeted microarray. Genes with the greatest fold change are shown (the effect of TNFα on DKK1 and FRZB expression was not significant). A full list of the genes included in the array and their full gene titles is given in Additional file 1, Table S1. (C) Real-time PCR validation of changes in mRNA expression for FRZB and WNT2 in response to dexamethasone (DEX) or TNFα. *P < 0.05, **P < 0.01 relative to control. Results shown are the combined results of three separate FLS lines.

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