Epigenetic contributions in the development of rheumatoid arthritis

Table 1 Classification of histone deacetylases and their inhibitors

Class	Member	Inhibitors	References
I	HDAC1	TSA, SAHA, ITF2357, FK228, VPA, MS-275	[27, 40, 47–51]
	HDAC2	TSA, SAHA, ITF2357, FK228, VPA
	HDAC3	TSA, SAHA, ITF2357, FK228, VPA, MS-275, MI192
	HDAC8	TSA, SAHA, ITF2357, FK228, VPA
II	HDAC4	TSA, SAHA, ITF2357, VPA	[27, 47, 49, 50]
	HDAC5	TSA, SAHA, ITF2357, VPA
	HDAC6	TSA, SAHA, ITF2357, VPA
	HDAC7	TSA, SAHA, ITF2357, VPA
	HDAC9	TSA, SAHA, ITF2357, VPA
	HDAC10	TSA, SAHA, ITF2357, VPA
III	SIRT1 to SIRT7	Nicotinamide	[52]
IV	HDAC11	-

Human histone deacetylases (HDACs) were classified into four subgroups. HDAC inhibitors summarized in the text are listed. SAHA, suberoylanilide hydroxamic acid; SIRT, sirtuin; TSA, trichostatin A; VPA, valproic acid.

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