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Table 2 Microarray gene expression of soleus muscle-fiber energy metabolism and gene products involved in fiber-type regulation

From: Muscle-fiber transdifferentiation in an experimental model of respiratory chain myopathy

Gene description (gene symbol) FC P value qvalue
Respiratory chain complex I    
NADH dehydrogenase (ubiquinone) 1α subcomplex, 4 (Ndufa4) -1.1 0.007 0.999
NADH dehydrogenase (ubiquinone) 1α/β subcomplex, 1 (Ndufab1) 1.0 0.507 0.999
NADH dehydrogenase (ubiquinone) 1α subcomplex, assembly factor 1 (Ndufaf1) -1.1 0.110 0.999
NADH dehydrogenase (ubiquinone) 1β subcomplex 3 (Ndufb3) -1.0 0.772 0.999
NADH dehydrogenase (ubiquinone) 1β subcomplex, 5 (Ndufb5) -1.1 0.036 0.999
NADH dehydrogenase (ubiquinone) 1 β subcomplex, 9 (Ndufb9) -1.0 0.286 0.999
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 (Ndufc1) -1.1 0.167 0.999
NADH dehydrogenase (ubiquinone) Fe-S protein 1 (Ndufs1) -1.1 0.045 0.999
NADH dehydrogenase subunit 1 (mt-ND1) -1.1 0.267 0.999
NADH dehydrogenase subunit 2 (mt-ND2) -1.1 0.087 0.999
NADH dehydrogenase subunit 4L (mt-ND4l) -1.1 0.004 0.999
NADH dehydrogenase subunit 5 (mt-ND5) -1.1 0.002 0.999
NADH dehydrogenase subunit 6 (mt-ND6) -1.2 0.364 0.999
Respiratory chain complex II    
Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (Sdhb) -1.4 0.00001 0.139
Respiratory chain complex III    
Ubiquinol-cytochrome c reductase binding protein (Uqcrb) -1.1 0.003 0.999
Ubiquinol-cytochrome c reductase core protein I (Uqcrc1) -1.0 0.677 0.999
Ubiquinol cytochrome c reductase core protein 2 (Uqcrc2) -1.1 0.039 0.999
Respiratory chain complex IV    
Cytochrome c oxidase, subunit Va (Cox5a) -1.1 0.205 0.999
Cytochrome c oxidase subunit Vb (Cox5b) -1.0 0.442 0.999
Cytochrome c oxidase, subunit VIa, polypeptide 2 (Cox6a2) -1.1 0.096 0.999
Cytochrome c oxidase, subunit VIc (Cox6c) -1.1 0.144 0.999
Cytochrome c oxidase subunit VIIb (Cox7b) 1.0 0.501 0.999
Cytochrome c oxidase, subunit VIIa 2 (Cox7a2) -1.1 0.006 0.999
Cytochrome c oxidase subunit VIIa polypeptide 2 like (Cox7a2l) -1.2 0.002 0.999
Cytochrome c oxidase subunit I (mt-Co1) -1.1 0.000 0.999
Cytochrome c oxidase subunit II (mt-Co2) -1.1 0.028 0.999
Respiratory chain complex V    
ATP synthase, F1 complex, γ polypeptide 1 (Atp5c1) 1.0 0.807 0.999
ATP synthase, F0 complex, subunit C3 (subunit 9) (Atp5g3) -1.1 0.080 0.999
ATP synthase GA binding protein transcription factor, α subunit: (Gabpa: Atp5j) -1.2 0.005 0.999
ATP synthase, F0 complex, subunit F2 (Atp5j2) 1.0 0.548 0.999
ATP synthase F0 subunit 6 (mt-atp6) -1.3 0.739 0.999
ATP synthase F0 subunit 8 (mt-atp8) -1.1 0.016 0.999
Glycolysis  
Phosphofructokinase, muscle (Pfkm) 2.1 1.00E-35 1.00E-35
Pyruvate kinase, muscle (Pkm2) 2.7 1.00E-35 1.00E-35
6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (Pfkfb3) 2.9 1.19E-13 3.26E-09
Glycogenolysis    
Phosphorylase, glycogen, muscle (Pygm) 1.3 1.78E-14 4.88E-10
Phosphoglucomutase 1 (Pgm1) 2.8 1.00E-35 1.00E-35
Phosphoglucomutase 2-like 1 (Pgm2l1) 2.2 1.19E-13 3.25E-09
Fatty acid ß-oxidation    
Carnitine palmitoyltransferase 1b, muscle (CPT1b) -1.4 3.52E-07 0.009
Hydroxyacyl-Coenzyme A dehydrogenase (Hadh) -1.6 2.02E-07 0.005
Regulator genes (muscle fiber-type switch)    
SRY (sex-determining region Y)-box 6 (Sox6) 5.2 1.00E-35 1.00E-35
Myogenic differentiation 1 (Myod1) 4.4 1.11E-16 3.06E-12
Myogenin (Myog) -3.7 1.78E-09 4.82E-05
Regulator of calcineurin 1 (Rcan1) -4.6 3.51E-13 9.61E-09
SIX homeobox 1 (Six1) 2.0 5.68E-12 1.55E-07
SIX homeobox 2 (Six2) 5.0 9.39E-13 2.57E-08
Myostatin (Mstn) 4.4 3.74E-13 1.03E-08
Estrogen-related receptor γ (Esrrg) -2.1 1.07E-10 2.91E-06
NFAT activating protein with ITAM motif 1 (Nfam1) -1.7 3.34E-08 8.96E-04
  1. The fold-change (FC) value indicates the relative amounts of transcripts in rats treated with zidovudine, compared with control animals. The Benjamini Hochberg q value indicates the false-discovery rate.