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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Y27, a novel derivative of 4-hydroxyquinoline-3-formamide, prevents the development of murine systemic lupus erythematosus-like diseases in MRL/lpr autoimmune mice and BDF1 hybrid mice

Figure 1

Structure of Y27 and its effect on CD4+CD25+ regulatory T (Treg) cells. (A) Structure of Y27. (B) Structure of H1521. (C) Y27 concentration-dependent enhancement of the suppressive capacity of CD4+CD25+ Treg cells in C57BL/6 mice in vitro. Suppressive activity of CD4+CD25+ Treg cells was expressed as percent suppression calculated as following: 100 × (cpm (CD4+CD25- Tconv) - cpm (CD4+CD25- Tconv + CD4+CD25+ Treg))/cpm (CD4+CD25- Tconv). Tconv, conventional CD4+CD25- effector T cells.

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Arthritis Research & Therapy

ISSN: 1478-6362

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