Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model

Table 1 Characteristics of primary Sjögren's syndrome, nonprimary Sjögren's syndrome sicca and control subjects

Characteristic	pSS (n= 24)	Non-pSS sicca (n= 16)	Controls (n= 25)
Age (years)	49.0 ± 15.8	52.8 ± 15.4	59.0 ± 12.0
Female:male	21:3	13:3	12:13
Ethnicity	24 Caucasian	16 Caucasian	25 Caucasian
Unstimulated whole saliva (ml/minute)	0.10 ± 0.14	0.12 ± 0.18	NA
Stimulated whole saliva (ml/minute)	0.31 ± 0.35	0.33 ± 0.40	NA
Schirmer's test (mm)	9.2 ± 7.6	14.8 ± 11.7	NA
Focal score	3.5 ± 1.2	0.5 ± 1.0	0
Sjögren's syndrome - A (positive:negative)	23:1	2:14	0:25
Sjögren's syndrome - B (positive:negative)	19:5	0:16	0:25

Data presented as the mean ± standard deviation. All primary Sjögren's syndrome (pSS) and non-pSS sicca patients were subjected to a complete American-European Consensus Group diagnostic work-up. NA, not assessed (in controls being head and neck cancer patients without parotid involvement, no functional tests were performed as all these patients were already scheduled for a neck dissection and functional tests were considered too much of a burden to the patients at that time).

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